Kinesin-1 heavy chain

UniProt P33176 Organism Homo sapiens Gene KIF5B, KNS, KNS1

Also known as: KIF5B, KNS, KNS1

Function

Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells.

Classification

Family (Pfam): PF00225 Kinesin
InterPro: Khc_C, Kinesin-like_fam, Kinesin_motor_CS, Kinesin_motor_dom, Kinesin_motor_dom_sf, P-loop_NTPase
Functional cluster: Protein Serine/Threonine Kinases

Experimental structures · PDB · 29

1BG2 X-ray 1.80A
1MKJ X-ray 2.70A
2P4N EM 9.00A
3J8X EM 5.00A
3J8Y EM 5.00A
4HNA X-ray 3.19A
4LNU X-ray 2.19A
5LT0 X-ray 2.00A
5LT1 X-ray 1.95A
5LT2 X-ray 2.60A
5LT3 X-ray 2.59A
5LT4 X-ray 2.88A
… and 17 more

A predicted model is available from AlphaFold.

Gene Ontology · 39

Drugs targeting this protein · 2

SELPERCATINIB inhibitor
PRALSETINIB inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Pleckstrin homology domain-containing family M member 2 3 shared papers
Syntabulin 1 shared papers
Kinesin light chain 2 1 shared papers
Syntaxin-1A 1 shared papers
Kinesin heavy chain 1 shared papers
Secreted effector protein SifA 1 shared papers
Janus kinase and microtubule-interacting protein 1 1 shared papers
Janus kinase and microtubule-interacting protein 1 1 shared papers
ADP-ribosylation factor-like protein 8B 2 shared papers
Kinesin-1 heavy chain 2 shared papers
Janus kinase and microtubule-interacting protein 1 1 shared papers
Amyloid-beta precursor-like protein 1 shared papers

Literature · 24 cited papers

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol. Cell. Proteomics · 2014
Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity. Mol. Biol. Cell · 2013
Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon. Phys. Biol. · 2012
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
Arl8 and SKIP act together to link lysosomes to kinesin-1. Dev. Cell · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components. J. Biol. Chem. · 2010
Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol. · 2010
… and 12 more in the literature graph

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