Cytokine receptor common subunit beta

Function

Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway.

Classification

Family (Pfam)

PF21460 IL3Rb_N

InterPro

FN3_dom, FN3_sf, Hempt_rcpt_S_F1_CS, Ig-like_fold, IL3_rcpt_beta, IL3RB_N

Functional cluster

Eukaryotic Transcription Factors & related

Experimental structures · PDB · 10

• 1C8P NMR
• 1EGJ X-ray 2.80A
• 1GH7 X-ray 3.00A
• 2GYS X-ray 2.70A
• 2NA8 NMR
• 2NA9 NMR
• 4NKQ X-ray 3.30A
• 5DWU X-ray 3.97A
• 6NMY X-ray 3.30A
• 8TLD EM 3.60A

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0009897 external side of plasma membrane
• GO:0030526 granulocyte macrophage colony-stimulating factor receptor complex
• GO:0005886 plasma membrane
• GO:0015026 coreceptor activity
• GO:0004896 cytokine receptor activity
• GO:0038023 signaling receptor activity
• GO:0007259 cell surface receptor signaling pathway via JAK-STAT
• GO:0036016 cellular response to interleukin-3
• GO:0038157 granulocyte-macrophage colony-stimulating factor signaling pathway
• GO:0016064 immunoglobulin mediated immune response
• GO:0038156 interleukin-3-mediated signaling pathway
• GO:0038043 interleukin-5-mediated signaling pathway
• GO:0008284 positive regulation of cell population proliferation
• GO:0070665 positive regulation of leukocyte proliferation
• GO:0007585 respiratory gaseous exchange by respiratory system
• GO:0032496 response to lipopolysaccharide
• GO:0007165 signal transduction

Disease associations

• surfactant metabolism dysfunction, pulmonary, 5 MONDO:0013712

Drugs targeting this protein · 1

• CIBINETIDE agonist

Related proteins · sequence + function similarity

• Interleukin-3 receptor class 2 subunit beta 0.96
• Cytokine receptor common subunit beta 0.96
• Interleukin-21 receptor 0.90
• Erythropoietin receptor 0.90
• Interleukin-2 receptor subunit beta 0.89
• Erythropoietin receptor 0.89
• Interleukin-2 receptor subunit beta 0.89
• Interleukin-2 receptor subunit beta 0.89
• Interleukin-4 receptor subunit alpha 0.89
• Erythropoietin receptor 0.88
• Thrombopoietin receptor 0.88
• Thrombopoietin receptor 0.88

Co-cited proteins · studied together in the literature

• Transmembrane protein 102 1 shared papers
• Interleukin-5 receptor subunit alpha 2 shared papers
• Granulocyte-macrophage colony-stimulating factor receptor subunit alpha 1 shared papers
• Granulocyte-macrophage colony-stimulating factor 1 shared papers
• Interleukin-5 1 shared papers

Literature · 13 cited papers

• Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB. J. Med. Genet. · 2011
• The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell · 2008
• CBAP interacts with the un-liganded common beta-subunit of the GM-CSF/IL-3/IL-5 receptor and induces apoptosis via mitochondrial dysfunction. Oncogene · 2008
• An improved resolution structure of the human beta common receptor involved in IL-3, IL-5 and GM-CSF signalling which gives better definition of the high-affinity binding epitope. Acta Crystallogr. F · 2006
• A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. · 2004
• Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration. Cell · 2001
• Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist. Blood · 2000
• The solution structure of the cytokine-binding domain of the common beta-chain of the receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3 and interleukin-5. J. Mol. Biol. · 2000
• The DNA sequence of human chromosome 22. Nature · 1999
• JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. Blood · 1998
• Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J. Clin. Invest. · 1997
• Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proc. Natl. Acad. Sci. U.S.A. · 1990
• … and 1 more in the literature graph