Cytidine deaminase

Function

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Classification

Family (Pfam)

PF00383 dCMP_cyt_deam_1

InterPro

APOBEC/CMP_deaminase_Zn-bd, CMP_dCMP_dom, Cyt/Deoxycyt_deaminase, Cyt_deam_tetra, Cytidine_deaminase-like

Functional cluster

Eukaryotic Transcription Factors & related

Experimental structures · PDB · 1

• 1MQ0 X-ray 2.40A

A predicted model is available from AlphaFold.

Gene Ontology · 16

• GO:0005829 cytosol
• GO:0005576 extracellular region
• GO:1904813 ficolin-1-rich granule lumen
• GO:0034774 secretory granule lumen
• GO:1904724 tertiary granule lumen
• GO:0004126 cytidine deaminase activity
• GO:0042802 identical protein binding
• GO:0001882 nucleoside binding
• GO:0042803 protein homodimerization activity
• GO:0008270 zinc ion binding
• GO:0071217 cellular response to external biotic stimulus
• GO:0006248 CMP catabolic process
• GO:0019858 cytosine metabolic process
• GO:0006249 dCMP catabolic process
• GO:0008655 pyrimidine-containing compound salvage
• GO:0044206 UMP salvage

Drugs targeting this protein · 1

• CEDAZURIDINE inhibitor

Related proteins · sequence + function similarity

• Cytidine deaminase 0.91
• Probable cytidine deaminase 0.79
• Cytidine deaminase 0.69
• Cytidine deaminase 0.67
• Cytidine deaminase 0.65
• Cytidine deaminase 0.64
• Cytidine deaminase 7 0.60
• Cytidine deaminase 8 0.59
• Cytidine deaminase 3 0.55
• tRNA-specific adenosine deaminase TAD2 0.55
• tRNA-specific adenosine-34 deaminase catalytic subunit ADAT2 0.55
• Cytidine deaminase 6 0.54

Literature · 7 cited papers

• The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
• Structure of human cytidine deaminase bound to a potent inhibitor. J. Med. Chem. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Isolation and characterization of the gene coding for human cytidine deaminase. Biochim. Biophys. Acta · 1998
• Growth inhibition of granulocyte-macrophage colony forming cells by human cytidine deaminase requires the catalytic function of the protein. Blood · 1998
• Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation. Biochem. Biophys. Res. Commun. · 1993
• Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA. Cancer Res. · 1994