Caspase-14

Function

Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF. Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function. Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD.

Classification

Family (Pfam)

PF00656 Peptidase_C14

InterPro

Caspase-like_dom_sf, Caspase_cys_AS, Pept_C14, Pept_C14_caspase, Pept_C14_p10, Pept_C14_p20, Pept_C14A

Functional cluster

Cytochrome P450 & Heme Enzymes

Gene Ontology · 12

• GO:0001533 cornified envelope
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0045095 keratin filament
• GO:0005654 nucleoplasm
• GO:0005634 nucleus
• GO:0004197 cysteine-type endopeptidase activity
• GO:0070268 cornification
• GO:0008544 epidermis development
• GO:0031424 keratinization
• GO:0043525 positive regulation of neuron apoptotic process
• GO:0006508 proteolysis

Disease associations

• ichthyosis, congenital, autosomal recessive 12 MONDO:0015018

Drugs targeting this protein · 1

• EMRICASAN inhibitor

Related proteins · sequence + function similarity

• Caspase-14 0.95
• Caspase-2 0.81
• Caspase-1-B 0.81
• Caspase-1-A 0.80
• Putative inactive caspase B 0.80
• Caspase a 0.79
• Caspase b 0.79
• Caspase Dronc 0.78
• Caspase-2 0.78
• Caspase-2 0.77
• Caspase-2 0.75
• Caspase-8 0.75

Co-cited proteins · studied together in the literature

• Caspase-14 1 shared papers

Literature · 14 cited papers

• Whole-Exome-Sequencing reveals small deletions in CASP14 in patients with autosomal recessive inherited ichthyosis. Acta Derm. Venereol. · 2017
• Caspase-14 expression impairs retinal pigment epithelium barrier function: potential role in diabetic macular edema. Biomed. Res. Int. · 2014
• Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation. Cell Death Dis. · 2014
• Kallikrein-related peptidase-7 regulates caspase-14 maturation during keratinocyte terminal differentiation by generating an intermediate form. J. Biol. Chem. · 2012
• Purification and characterization of active caspase-14 from human epidermis and development of the cleavage site-directed antibody. J. Cell. Biochem. · 2010
• Expression and characterization of constitutively active human caspase-14. Biochem. Biophys. Res. Commun. · 2006
• Stratum corneum-derived caspase-14 is catalytically active. FEBS Lett. · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Activation and substrate specificity of caspase-14. Biochemistry · 2004
• Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation. Biochem. Biophys. Res. Commun. · 2002
• Expression and transcriptional regulation of caspase-14 in simple and complex epithelia. Cell Death Differ. · 2002
• Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing. Cell Death Differ. · 2000
• … and 2 more in the literature graph