Translocator protein

Function

Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides.

Classification

Family (Pfam)

PF03073 TspO_MBR

InterPro

TspO/MBR-related_sf, TspO_MBR

Functional cluster

Prenyltransferases & Cell-Wall Biosynthesis Enzymes

Gene Ontology · 47

• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0005741 mitochondrial outer membrane
• GO:0005739 mitochondrion
• GO:0005497 androgen binding
• GO:0008503 benzodiazepine receptor activity
• GO:0015485 cholesterol binding
• GO:0120020 cholesterol transfer activity
• GO:0044325 transmembrane transporter binding
• GO:0030325 adrenal gland development
• GO:0048266 behavioral response to pain
• GO:0006700 C21-steroid hormone biosynthetic process
• GO:0071476 cellular hypotonic response
• GO:0071222 cellular response to lipopolysaccharide
• GO:0071294 cellular response to zinc ion
• GO:0006821 chloride transport
• GO:0042632 cholesterol homeostasis
• GO:0060242 contact inhibition
• GO:0008347 glial cell migration
• GO:0006783 heme biosynthetic process
• GO:0072656 maintenance of protein location in mitochondrion
• GO:0006820 monoatomic anion transport
• GO:1903579 negative regulation of ATP metabolic process
• GO:2000853 negative regulation of corticosterone secretion
• GO:0060253 negative regulation of glial cell proliferation
• GO:1901525 negative regulation of mitophagy
• GO:0045019 negative regulation of nitric oxide biosynthetic process
• GO:0031397 negative regulation of protein ubiquitination
• GO:0032720 negative regulation of tumor necrosis factor production
• GO:0014012 peripheral nervous system axon regeneration
• GO:0043065 positive regulation of apoptotic process
• GO:0051928 positive regulation of calcium ion transport
• GO:0060252 positive regulation of glial cell proliferation
• GO:0051901 positive regulation of mitochondrial depolarization
• GO:0062100 positive regulation of programmed necrotic cell death
• GO:2000379 positive regulation of reactive oxygen species metabolic process
• GO:0006626 protein targeting to mitochondrion
• GO:0042127 regulation of cell population proliferation
• GO:0032374 regulation of cholesterol transport
• GO:0050810 regulation of steroid biosynthetic process
• GO:1905144 response to acetylcholine
• GO:0010042 response to manganese ion
• GO:0032570 response to progesterone
• GO:0033574 response to testosterone
• GO:0010266 response to vitamin B1
• GO:0009410 response to xenobiotic stimulus
• GO:0008202 steroid metabolic process

Drugs targeting this protein · 3

• ONO-2952 antagonist
• EMAPUNIL agonist
• ALPIDEM partial agonist

Related proteins · sequence + function similarity

• Translocator protein 0.99
• Translocator protein 0.97
• Translocator protein 0.97
• Translocator protein 0.97
• Translocator protein 0.96
• Translocator protein 2 0.82
• Translocator protein 2 0.81
• Translocator protein 2 0.78
• Translocator protein homolog 0.72
• Translocator protein homolog 0.66
• Tryptophan-rich sensory protein 0.63
• Tryptophan-rich protein TspO 0.63

Co-cited proteins · studied together in the literature

• Translocator protein 2 shared papers
• Protein MOST-1 1 shared papers
• Peripheral-type benzodiazepine receptor-associated protein 1 1 shared papers
• Peripheral-type benzodiazepine receptor-associated protein 1 1 shared papers
• Peripheral-type benzodiazepine receptor-associated protein 1 1 shared papers
• Membrane-associated progesterone receptor component 1 1 shared papers
• Sigma intracellular receptor 2 1 shared papers
• Translocator protein 2 1 shared papers
• ADP/ATP translocase 4 1 shared papers
• Non-selective voltage-gated ion channel VDAC3 1 shared papers
• ADP/ATP translocase 1 1 shared papers
• Non-selective voltage-gated ion channel VDAC2 1 shared papers

Literature · 18 cited papers

• Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97. Int. J. Mol. Sci. · 2023
• TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood. Sci. Rep. · 2016
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype. Clin. Sci. · 2014
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol. Cell. Endocrinol. · 2010
• The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. Endocrinology · 2009
• Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers. Int. J. Oncol. · 2007
• Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol. Sci. · 2006
• Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells. Mol. Pharmacol. · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. · 2004
• … and 6 more in the literature graph