lmmol · Proteins

Sodium- and chloride-dependent GABA transporter 1

UniProt P30531 Organism Homo sapiens Gene GABATR, GABT1, GAT1, SLC6A1

Also known as: GABATR, GABT1, GAT1, SLC6A1

Function

Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse. The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity).

Classification

Family (Pfam)
PF00209 SNF
InterPro
Na/ntran_symport, Na/ntran_symport_GABA_GAT1, SNS_sf
Functional cluster
Membrane Transporters & GPCRs

Experimental structures · PDB · 5

A predicted model is available from AlphaFold.

Gene Ontology · 24

Disease associations

Drugs targeting this protein · 1

Related proteins · sequence + function similarity

Literature · 5 cited papers

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