LIM/homeobox protein Lhx1

UniProt P29674 Organism Xenopus laevis Gene lhx1, lim-1, lim1

Also known as: lhx1, lim-1, lim1

Function

Involved in the establishment of the body plan via the Spemann organizer during gastrulation. Transcriptional activator required to induce organizer gene expression downstream of siamois. Promotes head formation by binding to 5'-TAAT'-3' elements in the promoters of head organizer genes cer1 and gsc to stimulate expression. Binds as a complex with siamois and mix-A/mix.1 to the cer1 promoter, and with ldb1 and otx2 to the gsc promoter. Also involved in neural induction via the organizer, including a role in notochord formation. Acts synergistically with ldb1 and ssbp in subsequent axis formation. Involved in kidney development, acting synergistically with pax8 to establish the pronephric primordium in late gastrulae/early neurulae and with pax2 during pronephric morphogenesis in tailbud stages. Has a later role in mediating the activity of inhibitors of ventralization.

Classification

Family (Pfam): PF00046 Homeodomain, PF00412 LIM
InterPro: HD, Homeobox_CS, Homeodomain-like_sf, Lhx1/5_LIM1, Lhx1/5_LIM2, LIM_Homeobox_TF, Znf_LIM
Functional cluster: RNA-Polymerase II Transcription Factors

Gene Ontology · 26

Neighborhood · nearest proteins

Nearest neighbours of LIM/homeobox protein Lhx1: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

LIM domain-binding protein 1 6 shared papers
LIM/homeobox protein Lhx1 3 shared papers
LIM/homeobox protein Lhx1 1 shared papers
Paired box protein Pax-2-B 2 shared papers
Homeobox protein OTX2-A 2 shared papers
LIM/homeobox protein Lhx3 2 shared papers
Homeobox protein pv.1 1 shared papers
LIM/homeobox protein xLIM-2B 1 shared papers
LIM/homeobox protein Lhx5 2 shared papers
Paired box protein Pax-8 1 shared papers
Wilms tumor protein homolog A 1 shared papers
Homeobox protein Mix.1 1 shared papers

Literature · 23 cited papers

LIM-homeodomain genes as territory markers in the brainstem of adult and developing Xenopus laevis. J. Comp. Neurol. · 2005
LIM-homeodomain genes as developmental and adult genetic markers of Xenopus forebrain functional subdivisions. J. Comp. Neurol. · 2004
Selective degradation of excess Ldb1 by Rnf12/RLIM confers proper Ldb1 expression levels and Xlim-1/Ldb1 stoichiometry in Xenopus organizer functions. Development · 2003
Molecular link in the sequential induction of the Spemann organizer: direct activation of the cerberus gene by Xlim-1, Xotx2, Mix.1, and Siamois, immediately downstream from Nodal and Wnt signaling. Dev. Biol. · 2003
Conserved requirement of Lim1 function for cell movements during gastrulation. Dev. Cell · 2003
Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Proc. Natl. Acad. Sci. U.S.A. · 2002
The LIM-homeodomain gene family in the developing Xenopus brain: conservation and divergences with the mouse related to the evolution of the forebrain. J. Neurosci. · 2001
A study of Xlim1 function in the Spemann-Mangold organizer. Int. J. Dev. Biol. · 2001
Functional domains of the LIM homeodomain protein Xlim-1 involved in negative regulation, transactivation, and axis formation in Xenopus embryos. Dev. Biol. · 2001
A role for Xlim-1 in pronephros development in Xenopus laevis. Dev. Biol. · 2000
Xlim-1 and LIM domain binding protein 1 cooperate with various transcription factors in the regulation of the goosecoid promoter. Dev. Biol. · 2000
RNA interference for the organizer-specific gene Xlim-1 in Xenopus embryos. Biochem. Biophys. Res. Commun. · 2000
… and 11 more in the literature graph

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