Inositol monophosphatase 1

UniProt P29218 Organism Homo sapiens Gene IMPA, IMPA1 EC 3.1.3.25, 3.1.3.94

Also known as: IMPA, IMPA1

Function

Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder. Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate.

Classification

Family (Pfam): PF00459 Inositol_P
InterPro: IMPase, Inositol_monoP_metal-BS, Inositol_monoPase_Li-sen, Inositol_monophosphatase-like, Inositol_monophosphatase_CS
Functional cluster: Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 13

1AWB X-ray 2.50A
1IMA X-ray 2.30A
1IMB X-ray 2.20A
1IMC X-ray 2.60A
1IMD X-ray 2.60A
1IME X-ray 2.25A
1IMF X-ray 2.50A
2HHM X-ray 2.10A
4AS4 X-ray 1.70A
6GIU X-ray 1.39A
6GJ0 X-ray 1.73A
6ZK0 X-ray 1.47A
… and 1 more

A predicted model is available from AlphaFold.

Gene Ontology · 21

Disease associations

intellectual disability, autosomal recessive 59 MONDO:0015020

Drugs targeting this protein · 2

LITHIUM CARBONATE inhibitor
LITHIUM CITRATE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Inositol monophosphatase 1 2 shared papers
Inositol monophosphatase 1 2 shared papers
Inositol monophosphatase 1 1 shared papers
Inositol monophosphatase 2 1 shared papers
Inositol monophosphatase 2 1 shared papers

Literature · 17 cited papers

A homozygous loss-of-function mutation in inositol monophosphatase 1 (IMPA1) causes severe intellectual disability. Mol. Psychiatry · 2016
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Cloning, expression, purification, crystallization and X-ray analysis of inositol monophosphatase from Mus musculus and Homo sapiens. Acta Crystallogr. F · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1. J. Biol. Chem. · 2007
DNA sequence and analysis of human chromosome 8. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Brain inositol monophosphatase identified as a galactose 1-phosphatase. Brain Res. · 1997
Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA). Genomics · 1997
… and 5 more in the literature graph

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