lmmol · Proteins

Large ribosomal subunit protein eL13

UniProt P26373 Organism Homo sapiens Gene BBC1, RPL13

Also known as: BBC1, RPL13

Function

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). As part of the LSU, it is probably required for its formation and the maturation of rRNAs. Plays a role in bone development.

Classification

Family (Pfam)
PF01294 Ribosomal_L13e
InterPro
Ribosomal_eL13, Ribosomal_eL13_CS
Functional cluster
Membrane Translocases & Channels

Experimental structures · PDB · 153

A predicted model is available from AlphaFold.

Gene Ontology · 17

Disease associations

Drugs targeting this protein · 2

Related proteins · sequence + function similarity

Literature · 19 cited papers

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