Integrin beta-7

Function

Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin.

Classification

Family (Pfam)

PF07974 EGF_2, PF08725 Integrin_b_cyt, PF00362 Integrin_beta, PF17205 PSI_integrin

InterPro

EGF_extracell, Integrin_beta_N, Integrin_bsu, Integrin_bsu_cyt_dom, Integrin_bsu_tail, Integrin_bsu_tail_dom_sf, Integrin_bsu_VWA, Integrin_dom_sf, Integrin_I-EGF_CS, PSI, vWFA_dom_sf

Functional cluster

Secreted Growth Factors & Cytokines

Experimental structures · PDB · 9

• 2BRQ X-ray 2.10A
• 3V4P X-ray 3.15A
• 3V4V X-ray 3.10A
• 8ZJF EM 2.70A
• 9P95 EM 3.05A
• 9P96 EM 3.10A
• 9P97 EM 2.92A
• 9P98 EM 2.93A
• 9P99 EM 3.37A

A predicted model is available from AlphaFold.

Gene Ontology · 24

• GO:0009986 cell surface
• GO:0070062 extracellular exosome
• GO:0005925 focal adhesion
• GO:0034669 integrin alpha4-beta7 complex
• GO:0008305 integrin complex
• GO:0016020 membrane
• GO:0005886 plasma membrane
• GO:0043235 receptor complex
• GO:0050839 cell adhesion molecule binding
• GO:0005178 integrin binding
• GO:0046872 metal ion binding
• GO:0001618 virus receptor activity
• GO:0007155 cell adhesion
• GO:0033627 cell adhesion mediated by integrin
• GO:0098609 cell-cell adhesion
• GO:0007160 cell-matrix adhesion
• GO:0003366 cell-matrix adhesion involved in ameboidal cell migration
• GO:0034113 heterotypic cell-cell adhesion
• GO:0002387 immune response in gut-associated lymphoid tissue
• GO:0007229 integrin-mediated signaling pathway
• GO:0050900 leukocyte migration
• GO:0050901 leukocyte tethering or rolling
• GO:0043113 receptor clustering
• GO:0034446 substrate adhesion-dependent cell spreading

Drugs targeting this protein · 1

• FIRATEGRAST antagonist

Related proteins · sequence + function similarity

• Integrin beta-7 0.99
• Integrin beta-6 0.82
• Integrin beta-2 0.82
• Integrin beta-6 0.81
• SCO-spondin 0.80
• Laminin subunit beta-2 0.79
• SCO-spondin 0.79
• Laminin subunit gamma-3 0.79
• Integrin beta-2 0.79
• Laminin subunit gamma-3 0.79
• Disintegrin and metalloproteinase domain-containing protein 15 0.79
• Laminin subunit beta-2 0.79

Co-cited proteins · studied together in the literature

• Integrin alpha-E 3 shared papers
• Envelope glycoprotein gp160 1 shared papers
• Integrin beta-6 1 shared papers
• Platelet glycoprotein Ib alpha chain 1 shared papers
• Integrin beta-2 1 shared papers
• Integrin beta-3 1 shared papers
• Filamin-A 1 shared papers

Literature · 15 cited papers

• Cryo-EM structure of I domain-containing integrin alphaEbeta7. Biochem. Biophys. Res. Commun. · 2024
• Structural specializations of alpha(4)beta(7), an integrin that mediates rolling adhesion. J. Cell Biol. · 2012
• Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk. J. Biol. Chem. · 2009
• HIV-1 envelope protein binds to and signals through integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells. Nat. Immunol. · 2008
• The molecular basis of filamin binding to integrins and competition with talin. Mol. Cell · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Bistable regulation of integrin adhesiveness by a bipolar metal ion cluster. Nat. Struct. Biol. · 2003
• Integrins: bidirectional, allosteric signaling machines. Cell · 2002
• The role of alpha and beta chains in ligand recognition by beta 7 integrins. J. Biol. Chem. · 2000
• Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. Int. Immunol. · 1990
• Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. J. Biol. Chem. · 1991
• Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. Int. Immunol. · 1991
• … and 3 more in the literature graph