lmmol · Proteins

Atypical chemokine receptor 3

UniProt P25106 Organism Homo sapiens Gene ACKR3, CMKOR1, CXCR7, GPR159, RDC1

Also known as: ACKR3, CMKOR1, CXCR7, GPR159, RDC1

Function

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels. Acts as a receptor for SHLP2, mediating its effects on activation of proopiomelanocortin neurons in the arcuate nucleus of the hypothalamus which leads to suppression of food intake and increased energy expenditure.

Classification

Family (Pfam)
PF00001 7tm_1
InterPro
ACKR3, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, GPER1-like
Functional cluster
G Protein-Coupled Receptors

Experimental structures · PDB · 14

A predicted model is available from AlphaFold.

Gene Ontology · 26

Disease associations

Neighborhood · nearest proteins

ACKR3ACKR3Ackr3Ackr3CXCL12MT-RNR2ACKR4
Nearest neighbours of Atypical chemokine receptor 3: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 27 cited papers

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