Platelet-activating factor receptor

Function

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

GPCR_Rhodpsn, GPCR_Rhodpsn_7TM, PAF_rcpt

Functional cluster

G Protein-Coupled Receptors

Experimental structures · PDB · 3

• 5ZKP X-ray 2.81A
• 5ZKQ X-ray 2.90A
• 8XYD EM 2.90A

A predicted model is available from AlphaFold.

Gene Ontology · 15

• GO:0016020 membrane
• GO:0005886 plasma membrane
• GO:0030667 secretory granule membrane
• GO:0070821 tertiary granule membrane
• GO:0045028 G protein-coupled purinergic nucleotide receptor activity
• GO:0004930 G protein-coupled receptor activity
• GO:0001530 lipopolysaccharide binding
• GO:0001875 lipopolysaccharide immune receptor activity
• GO:0005543 phospholipid binding
• GO:0004992 platelet activating factor receptor activity
• GO:0006935 chemotaxis
• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0006955 immune response
• GO:0006954 inflammatory response
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway

Drugs targeting this protein · 2

• MINOPAFANT antagonist
• RUPATADINE antagonist

Related proteins · sequence + function similarity

• Platelet-activating factor receptor 0.99
• Platelet-activating factor receptor 0.99
• Platelet-activating factor receptor 0.99
• Platelet-activating factor receptor 0.99
• Platelet-activating factor receptor 0.99
• Platelet-activating factor receptor 0.99
• G protein-coupled receptor 183 0.94
• G protein-coupled receptor 183 0.94
• G protein-coupled receptor 183-B 0.94
• G protein-coupled receptor 183 0.94
• Probable G protein-coupled receptor 174 0.94
• G protein-coupled receptor 65 0.93

Co-cited proteins · studied together in the literature

• Dual specificity mitogen-activated protein kinase kinase 3 1 shared papers
• Beta-arrestin-1 1 shared papers

Literature · 10 cited papers

• Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. J. Immunol. · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. · 1999
• Cloning of a human platelet-activating factor receptor gene: evidence for an intron in the 5'-untranslated region. Am. J. Respir. Cell Mol. Biol. · 1993
• Molecular cloning and expression of platelet-activating factor receptor from human leukocytes. J. Biol. Chem. · 1991
• Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. Biochem. Biophys. Res. Commun. · 1991
• The human leukocyte platelet-activating factor receptor. cDNA cloning, cell surface expression, and construction of a novel epitope-bearing analog. J. Biol. Chem. · 1992
• The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. Genomics · 1992
• Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. Biochem. Biophys. Res. Commun. · 1992