Endothelin receptor type B

Function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Classification

Family (Pfam)

PF00001 7tm_1

InterPro

Endthln_rcpt, ETB_rcpt, GPCR_endothelin_rcpt, GPCR_Rhodpsn, GPCR_Rhodpsn_7TM

Functional cluster

MFS & Drug-Efflux Transporters

Experimental structures · PDB · 18

• 5GLH X-ray 2.80A
• 5GLI X-ray 2.50A
• 5X93 X-ray 2.20A
• 5XPR X-ray 3.60A
• 6IGK X-ray 2.00A
• 6IGL X-ray 2.70A
• 6K1Q X-ray 2.70A
• 6LRY X-ray 3.00A
• 8HBD EM 2.99A
• 8HCX EM 3.50A
• 8IY5 EM 2.80A
• 8IY6 EM 3.13A
• … and 6 more

A predicted model is available from AlphaFold.

Gene Ontology · 49

• GO:0031965 nuclear membrane
• GO:0005886 plasma membrane
• GO:0004962 endothelin receptor activity
• GO:0017046 peptide hormone binding
• GO:0031702 type 1 angiotensin receptor binding
• GO:0032341 aldosterone metabolic process
• GO:0070588 calcium ion transmembrane transport
• GO:0019722 calcium-mediated signaling
• GO:0060070 canonical Wnt signaling pathway
• GO:0007166 cell surface receptor signaling pathway
• GO:0071222 cellular response to lipopolysaccharide
• GO:0006182 cGMP biosynthetic process
• GO:0160093 chordate pharynx development
• GO:0048066 developmental pigmentation
• GO:0086100 endothelin receptor signaling pathway
• GO:0048484 enteric nervous system development
• GO:0035645 enteric smooth muscle cell differentiation
• GO:0042045 epithelial fluid transport
• GO:0061028 establishment of endothelial barrier
• GO:0010467 gene expression
• GO:0030202 heparin proteoglycan metabolic process
• GO:0048246 macrophage chemotaxis
• GO:0030318 melanocyte differentiation
• GO:0007194 negative regulation of adenylate cyclase activity
• GO:0043066 negative regulation of apoptotic process
• GO:0014043 negative regulation of neuron maturation
• GO:0051248 negative regulation of protein metabolic process
• GO:0000122 negative regulation of transcription by RNA polymerase II
• GO:0007399 nervous system development
• GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
• GO:0072112 podocyte differentiation
• GO:0008284 positive regulation of cell population proliferation
• GO:0007204 positive regulation of cytosolic calcium ion concentration
• GO:0060406 positive regulation of penile erection
• GO:0035810 positive regulation of urine volume
• GO:0071806 protein transmembrane transport
• GO:0050678 regulation of epithelial cell proliferation
• GO:0031620 regulation of fever generation
• GO:0002027 regulation of heart rate
• GO:0097018 renal albumin absorption
• GO:0035812 renal sodium excretion
• GO:0070294 renal sodium ion absorption
• GO:0002001 renin secretion into blood stream
• GO:1990839 response to endothelin
• GO:0048265 response to pain
• GO:1904383 response to sodium phosphate
• GO:0042310 vasoconstriction
• GO:0042311 vasodilation
• GO:0014826 vein smooth muscle contraction

Disease associations

• Hirschsprung disease, susceptibility to, 1 MONDO:0007723
• Waardenburg syndrome type 4A MONDO:0010192
• Hirschsprung disease, susceptibility to, 2 MONDO:0010833
• ABCD syndrome MONDO:0010895

Drugs targeting this protein · 9

• AMBRISENTAN antagonist
• MACITENTAN antagonist
• SITAXENTAN SODIUM antagonist
• APROCITENTAN antagonist
• DARUSENTAN antagonist
• SITAXENTAN antagonist
• ENRASENTAN antagonist
• TEZOSENTAN antagonist
• BOSENTAN antagonist

Neighborhood · nearest proteins

Related proteins · sequence + function similarity

• Endothelin receptor type B 1.00
• Endothelin receptor type B 0.99
• Endothelin receptor type B 0.99
• Endothelin receptor type B 0.99
• Endothelin receptor type B 0.99
• Endothelin receptor type B 0.98
• Endothelin receptor type B 0.98
• Endothelin-1 receptor 0.92
• Endothelin receptor type B 0.91
• Endothelin-1 receptor 0.90
• Endothelin-1 receptor 0.89
• Endothelin-1 receptor 0.89

Co-cited proteins · studied together in the literature

• Endothelin-1 receptor 3 shared papers
• Endothelin-3 4 shared papers
• Microphthalmia-associated transcription factor 1 shared papers
• Proto-oncogene tyrosine-protein kinase receptor Ret 2 shared papers
• Endothelin-2 1 shared papers
• Endothelin-1 1 shared papers
• Glial cell line-derived neurotrophic factor 1 shared papers

Literature · 28 cited papers

• EDNRB mutations cause Waardenburg syndrome type II in the heterozygous state. Hum. Mutat. · 2017
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and analysis of human chromosome 13. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Significance of novel endothelin-B receptor gene polymorphisms in Hirschsprung's disease: predominance of a novel variant (561C/T) in patients with co-existing Down's syndrome. Mol. Cell. Probes · 2003
• SOX10 mutations in chronic intestinal pseudo-obstruction suggest a complex physiopathological mechanism. Hum. Genet. · 2002
• ABCD syndrome is caused by a homozygous mutation in the EDNRB gene. Am. J. Med. Genet. · 2002
• Functional characterization of three mutations of the endothelin B receptor gene in patients with Hirschsprung's disease: evidence for selective loss of Gi coupling. Mol. Med. · 2001
• A consanguineous family with Hirschsprung disease, microcephaly, and mental retardation (Goldberg-Shprintzen syndrome). J. Med. Genet. · 1999
• Novel endothelin B receptor transcripts with the potential of generating a new receptor. Gene · 1999
• Phenotypic variation in a family with mutations in two Hirschsprung-related genes (RET and endothelin receptor B). Hum. Genet. · 1998
• Mutations in Hirschsprung disease: when does a mutation contribute to the phenotype. Eur. J. Hum. Genet. · 1997
• … and 16 more in the literature graph