D-alanyl-D-alanine carboxypeptidase DacB
Also known as: JW3149, b3182, dacB
Function
Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction.
Classification
- Family (Pfam)
- PF02113 Peptidase_S13
- InterPro
- Beta-lactam/transpept-like, Peptidase_S13
- Functional cluster
- Cell-Envelope & Peptidoglycan Enzymes
Experimental structures · PDB · 6
A predicted model is available from AlphaFold.
Gene Ontology · 15
- GO:0042597 periplasmic space
- GO:0005886 plasma membrane
- GO:0004180 carboxypeptidase activity
- GO:0004175 endopeptidase activity
- GO:0008658 penicillin binding
- GO:0004185 serine-type carboxypeptidase activity
- GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
- GO:0004252 serine-type endopeptidase activity
- GO:0071555 cell wall organization
- GO:0043093 FtsZ-dependent cytokinesis
- GO:0009252 peptidoglycan biosynthetic process
- GO:0000270 peptidoglycan metabolic process
- GO:0006508 proteolysis
- GO:0008360 regulation of cell shape
- GO:0046677 response to antibiotic
Drugs targeting this protein · 85
- CEFOTAXIME SODIUM inhibitor
- AMOXICILLIN inhibitor
- CEFUROXIME AXETIL inhibitor
- PENICILLIN G SODIUM inhibitor
- CEFAMANDOLE inhibitor
- CYCLACILLIN inhibitor
- MOXALACTAM DISODIUM inhibitor
- CEPHALEXIN HYDROCHLORIDE inhibitor
- CEFOPERAZONE SODIUM inhibitor
- CEFAZOLIN SODIUM inhibitor
- CEFOXITIN SODIUM inhibitor
- CEPHALEXIN inhibitor
- LORACARBEF inhibitor
- CEFPIRAMIDE SODIUM inhibitor
- AMPICILLIN SODIUM inhibitor
- CEFTAZIDIME SODIUM inhibitor
- PIPERACILLIN SODIUM inhibitor
- PENICILLIN V POTASSIUM inhibitor
- TICARCILLIN DISODIUM inhibitor
- CEFEPIME HYDROCHLORIDE inhibitor
- BACAMPICILLIN HYDROCHLORIDE inhibitor
- CEPHALOGLYCIN inhibitor
- CEFTIBUTEN DIHYDRATE inhibitor
- CARBENICILLIN INDANYL SODIUM inhibitor
- CEFONICID SODIUM inhibitor
- CEFPODOXIME PROXETIL inhibitor
- CEFACLOR inhibitor
- CEFTIZOXIME SODIUM inhibitor
- CEPHAPIRIN SODIUM inhibitor
- CEFORANIDE inhibitor
- CEFOTETAN DISODIUM inhibitor
- CEFMETAZOLE SODIUM inhibitor
- CEFTOLOZANE SULFATE inhibitor
- PENICILLIN G POTASSIUM inhibitor
- ERTAPENEM SODIUM inhibitor
- RAZUPENEM inhibitor
- FAROPENEM MEDOXOMIL inhibitor
- MEROPENEM inhibitor
- TEMOCILLIN inhibitor
- ERTAPENEM inhibitor
- CEFIXIME inhibitor
- FLOMOXEF inhibitor
- AZTREONAM inhibitor
- CEPHRADINE inhibitor
- CEFTIBUTEN inhibitor
- PHENETHICILLIN inhibitor
- CEFAMANDOLE NAFATE inhibitor
- TALAMPICILLIN inhibitor
- CEPHALOTHIN SODIUM inhibitor
- CEFADROXIL inhibitor
- CEFPODOXIME inhibitor
- MEZLOCILLIN SODIUM inhibitor
- AMPICILLIN inhibitor
- SULOPENEM inhibitor
- PENAMECILLIN inhibitor
- TEBIPENEM PIVOXIL inhibitor
- CEFUROXIME SODIUM inhibitor
- FLOXACILLIN inhibitor
- CEFTIOFUR inhibitor
- CEFODIZIME inhibitor
- PIVAMPICILLIN inhibitor
- CEFMENOXIME HYDROCHLORIDE inhibitor
- CEFSULODIN inhibitor
- CEFTAROLINE FOSAMIL ACETATE inhibitor
- AZTREONAM LYSINE inhibitor
- PENICILLIN G BENZATHINE inhibitor
- CEFIDEROCOL inhibitor
- CEFIDEROCOL SULFATE TOSYLATE inhibitor
- CEFILAVANCIN inhibitor
- CEFOTIAM HYDROCHLORIDE inhibitor
- DORIPENEM MONOHYDRATE inhibitor
- IMIPENEM inhibitor
- CEFTAZIDIME inhibitor
- CEFDITOREN PIVOXIL inhibitor
- SULOPENEM ETZADROXIL inhibitor
- DORIPENEM inhibitor
- CEFTAROLINE FOSAMIL inhibitor
- CEFTOBIPROLE inhibitor
- CEFPROZIL, (E)- inhibitor
- FAROPENEM inhibitor
- CARBENICILLIN DISODIUM inhibitor
- CEFTRIAXONE SODIUM inhibitor
- PENICILLIN V inhibitor
- CEFPIROME inhibitor
- CEFDINIR inhibitor
Related proteins · sequence + function similarity
- D-alanyl-D-alanine carboxypeptidase DacB 0.90
- Beta-lactamase SHV-46 0.70
- Beta-lactamase SHV-5 0.70
- Beta-lactamase SHV-5 0.70
- Beta-lactamase SHV-29 0.70
- Beta-lactamase SHV-2 0.70
- Beta-lactamase SHV-2 0.70
- Beta-lactamase SHV-13 0.70
- Beta-lactamase SHV-34 0.70
- Beta-lactamase SHV-2 0.70
- Beta-lactamase SHV-2 0.70
- Beta-lactamase SHV-8 0.70
Literature · 5 cited papers
- Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol. Syst. Biol. · 2006
- Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics. Biochemistry · 2006
- The complete genome sequence of Escherichia coli K-12. Science · 1997
- Penicillin-binding protein 4 of Escherichia coli: molecular cloning of the dacB gene, controlled overexpression, and alterations in murein composition. Mol. Microbiol. · 1991
- Penicillin-binding protein 4 of Escherichia coli shows a novel type of primary structure among penicillin-interacting proteins. FEMS Microbiol. Lett. · 1991
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