Receptor-type tyrosine-protein phosphatase beta

Function

Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Classification

Family (Pfam)

PF00041 fn3, PF18861 PTP_tm, PF00102 Y_phosphatase

InterPro

FN3_dom, FN3_sf, Ig-like_fold, Prot-tyrosine_phosphatase-like, PTP_cat, PTPRJ_TM, RTP_Phos/Ushers, Tyr_Pase_AS, Tyr_Pase_cat, Tyr_Pase_dom

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 14

• 2AHS X-ray 2.10A
• 2H02 X-ray 2.30A
• 2H03 X-ray 1.65A
• 2H04 X-ray 2.30A
• 2HC1 X-ray 1.30A
• 2HC2 X-ray 1.40A
• 2I3R X-ray 1.85A
• 2I3U X-ray 1.85A
• 2I4E X-ray 1.75A
• 2I4G X-ray 1.65A
• 2I4H X-ray 2.15A
• 2I5X X-ray 1.70A
• … and 2 more

A predicted model is available from AlphaFold.

Gene Ontology · 12

• GO:0005886 plasma membrane
• GO:0043235 receptor complex
• GO:0035579 specific granule membrane
• GO:0070821 tertiary granule membrane
• GO:0045296 cadherin binding
• GO:0030293 transmembrane receptor protein tyrosine kinase inhibitor activity
• GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
• GO:0001525 angiogenesis
• GO:0016311 dephosphorylation
• GO:0001649 osteoblast differentiation
• GO:0006796 phosphate-containing compound metabolic process
• GO:0006470 protein dephosphorylation

Drugs targeting this protein · 1

• RAZUPROTAFIB inhibitor

Related proteins · sequence + function similarity

• Receptor-type tyrosine-protein phosphatase beta 0.99
• Tyrosine-protein phosphatase 10D 0.79
• Phosphatidylinositol phosphatase PTPRQ 0.79
• Phosphatidylinositol phosphatase PTPRQ 0.78
• Fibronectin type III domain-containing protein 7 0.78
• Fibronectin type III domain-containing protein 7 0.77
• Phosphatidylinositol phosphatase PTPRQ 0.77
• Receptor-type tyrosine-protein phosphatase eta 0.76
• Tenascin-R 0.75
• Receptor-type tyrosine-protein phosphatase O 0.75
• Tenascin-R 0.74
• Receptor-type tyrosine-protein phosphatase eta 0.73

Co-cited proteins · studied together in the literature

• Insulin-like growth factor-binding protein 2 1 shared papers
• Angiopoietin-1 receptor 2 shared papers
• Vascular endothelial growth factor receptor 2 1 shared papers
• Angiopoietin-2 1 shared papers
• Receptor-type tyrosine-protein phosphatase delta 1 shared papers
• Receptor-type tyrosine-protein phosphatase gamma 2 shared papers
• Receptor-type tyrosine-protein phosphatase beta 1 shared papers
• Receptor-type tyrosine-protein phosphatase epsilon 2 shared papers
• Receptor-type tyrosine-protein phosphatase alpha 1 shared papers
• Angiopoietin-1 receptor 1 shared papers
• Tyrosine-protein phosphatase non-receptor type 18 1 shared papers
• Tyrosine-protein phosphatase non-receptor type 9 1 shared papers

Literature · 12 cited papers

• Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase beta and the IGF-I receptor to regulate IGF-I-stimulated signaling. Mol. Cell. Biol. · 2012
• VE-PTP controls blood vessel development by balancing Tie-2 activity. J. Cell Biol. · 2009
• Large-scale structural analysis of the classical human protein tyrosine phosphatome. Cell · 2009
• Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. FASEB J. · 2009
• Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells. Angiogenesis · 2009
• The full-ORF clone resource of the German cDNA consortium. BMC Genomics · 2007
• Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery. Acta Crystallogr. D · 2006
• Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta. Bioorg. Med. Chem. Lett. · 2006
• The finished DNA sequence of human chromosome 12. Nature · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. Anal. Chem. · 2004
• Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. · 1990