Antibiotic resistant DNA gyrase subunit B
Also known as: gyrB
Function
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
Classification
- Family (Pfam)
- PF00204 DNA_gyraseB, PF00986 DNA_gyraseB_C, PF21249 GyrB_hook, PF18053 GyrB_insert, PF02518 HATPase_c, PF01751 Toprim
- InterPro
- DNA_gyrase_B_C, GyrB, GyrB_hook, GyrB_insert, HATPase_C_sf, HATPase_dom, Ribosomal_Su5_D2-typ_SF, Ribsml_uS5_D2-typ_fold_subgr, Topo_IIA, Topo_IIA-like_dom_sf, Topo_IIA_B, Topo_IIA_B_C, Topo_IIA_bsu_dom2, TopoIIA_CS, TOPRIM_dom, TOPRIM_GyrB
- Functional cluster
- S-Adenosylmethionine Synthases & related
Gene Ontology · 9
- GO:0005694 chromosome
- GO:0005737 cytoplasm
- GO:0005524 ATP binding
- GO:0003677 DNA binding
- GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
- GO:0046872 metal ion binding
- GO:0006265 DNA topological change
- GO:0006261 DNA-templated DNA replication
- GO:0046677 response to antibiotic
Drugs targeting this protein · 2
- ZOLIFLODACIN inhibitor
- ENOXACIN inhibitor
Related proteins · sequence + function similarity
- DNA gyrase subunit B 1.00
- DNA gyrase subunit B 0.93
- DNA gyrase subunit B 0.93
- DNA gyrase subunit B 0.93
- DNA gyrase subunit B 0.93
- DNA gyrase subunit B 0.93
- DNA gyrase subunit B 0.92
- DNA gyrase subunit B 0.91
- DNA gyrase subunit B 0.91
- DNA gyrase subunit B 0.91
- DNA gyrase subunit B 0.91
- DNA gyrase subunit B 0.88
Literature · 2 cited papers
- Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae. Antimicrob. Agents Chemother. · 2015
- Characterization of a gyrB mutation responsible for low-level nalidixic acid resistance in Neisseria gonorrhoeae. Antimicrob. Agents Chemother. · 1991
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