Aromatic-L-amino-acid decarboxylase

Function

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-5-hydroxytryptophan to serotonin.

Classification

Family (Pfam)

PF00282 Pyridoxal_deC

InterPro

Aromatic_deC, PyrdxlP-dep_de-COase, PyrdxlP-dep_Trfase, PyrdxlP-dep_Trfase_major, PyrdxlP-dep_Trfase_small, Pyridoxal-P_BS

Functional cluster

Oxidoreductases & Polyketide Synthases

Experimental structures · PDB · 8

• 3RBF X-ray 2.90A
• 3RBL X-ray 3.24A
• 3RCH X-ray 2.80A
• 8OR9 X-ray 1.90A
• 8ORA X-ray 2.40A
• 9GNS X-ray 1.93A
• 9HRH X-ray 1.70A
• 9HRI X-ray 2.05A

A predicted model is available from AlphaFold.

Gene Ontology · 13

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0070062 extracellular exosome
• GO:0036467 5-hydroxy-L-tryptophan decarboxylase activity
• GO:0004058 aromatic-L-amino-acid decarboxylase activity
• GO:0019899 enzyme binding
• GO:0036468 L-dopa decarboxylase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0006520 amino acid metabolic process
• GO:0019752 carboxylic acid metabolic process
• GO:0006584 catecholamine metabolic process
• GO:0042416 dopamine biosynthetic process
• GO:0042427 serotonin biosynthetic process

Disease associations

• aromatic L-amino acid decarboxylase deficiency MONDO:0012084

Drugs targeting this protein · 3

• BENSERAZIDE inhibitor
• CARBIDOPA inhibitor
• FOSCARBIDOPA inhibitor

Related proteins · sequence + function similarity

• Aromatic-L-amino-acid decarboxylase 0.98
• Aromatic-L-amino-acid decarboxylase 0.98
• Aromatic-L-amino-acid decarboxylase 0.97
• Aromatic-L-amino-acid decarboxylase 0.95
• Aromatic-L-amino-acid decarboxylase 0.94
• Tyrosine decarboxylase 1 0.90
• Aromatic-L-amino-acid decarboxylase 0.89
• Aromatic-L-amino-acid decarboxylase 0.89
• Aromatic-L-amino-acid decarboxylase 0.89
• Aromatic-L-amino-acid decarboxylase 0.88
• Histidine decarboxylase 0.88
• 3,4-dihydroxyphenylacetaldehyde synthase 0.88

Literature · 13 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases. Proc. Natl. Acad. Sci. U.S.A. · 2011
• Identification and characterization of a novel form of the human L-dopa decarboxylase mRNA. Neurochem. Res. · 2004
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis. Neurology · 2004
• Levodopa-responsive aromatic L-amino acid decarboxylase deficiency. Ann. Neurol. · 2004
• The DNA sequence of human chromosome 7. Nature · 2003
• Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. · 1999
• Identification of a neuron-specific promoter of human aromatic L-amino acid decarboxylase gene. Brain Res. Mol. Brain Res. · 1993
• Isolation and characterization of a cDNA clone encoding human aromatic L-amino acid decarboxylase. Biochem. Biophys. Res. Commun. · 1989
• Human dopa decarboxylase: localization to human chromosome 7p11 and characterization of hepatic cDNAs. Genomics · 1992
• Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesis. Biochemistry · 1992
• … and 1 more in the literature graph