Arachidonate 5-lipoxygenase-activating protein

UniProt P20292 Organism Homo sapiens Gene ALOX5AP, FLAP

Also known as: ALOX5AP, FLAP

Function

Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.

Classification

Family (Pfam): PF01124 MAPEG
InterPro: 5_LipOase_AP, FLAP/GST2/LTC4S_CS, MAPEG, MAPEG-like_dom_sf, Membr-assoc_MAPEG
Functional cluster: Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 4

2Q7M X-ray 4.25A
2Q7R X-ray 4.00A
6VGC X-ray 2.37A
6VGI X-ray 2.61A

A predicted model is available from AlphaFold.

Gene Ontology · 13

Disease associations

obsolete susceptibility to ischemic stroke MONDO:0020671

Drugs targeting this protein · 3

FIBOFLAPON inhibitor
FIBOFLAPON SODIUM inhibitor
VELIFLAPON inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Arachidonate 5-lipoxygenase-activating protein 1 shared papers
Polyunsaturated fatty acid 5-lipoxygenase 2 shared papers
Leukotriene C4 synthase 1 shared papers

Literature · 12 cited papers

N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein. Biochem. Biophys. Res. Commun. · 2009
Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science · 2007
No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population. Genet. Med. · 2007
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
The DNA sequence and analysis of human chromosome 13. Nature · 2004
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat. Genet. · 2004
5-lipoxygenase-activating protein is an arachidonate binding protein. FEBS Lett. · 1993
5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J. Exp. Med. · 1993
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature · 1990
Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP). J. Biol. Chem. · 1991

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