Thymidine phosphorylase

Function

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.

Classification

Family (Pfam)

PF02885 Glycos_trans_3N, PF00591 Glycos_transf_3, PF07831 PYNP_C

InterPro

Glycosyl_Trfase_fam3, Glycosyl_Trfase_fam3_N_dom, Glycosyl_Trfase_fam3_N_dom_sf, Nuc_phospho_transferase, PYNP-like_C_sf, PYNP_C, Pyrmidine_PPas_bac/euk, Pyrmidine_PPase_CS, Thymidine/pyrmidine_PPase

Functional cluster

Membrane Channels & Lipid-Anchored Proteins

Experimental structures · PDB · 4

• 1UOU X-ray 2.11A
• 2J0F X-ray 2.31A
• 2WK5 X-ray 2.99A
• 2WK6 X-ray 2.50A

A predicted model is available from AlphaFold.

Gene Ontology · 11

• GO:0005829 cytosol
• GO:0004645 1,4-alpha-oligoglucan phosphorylase activity
• GO:0008083 growth factor activity
• GO:0042803 protein homodimerization activity
• GO:0009032 thymidine phosphorylase activity
• GO:0001525 angiogenesis
• GO:0030154 cell differentiation
• GO:0006935 chemotaxis
• GO:0046074 dTMP catabolic process
• GO:0006206 pyrimidine nucleobase metabolic process
• GO:0006213 pyrimidine nucleoside metabolic process

Disease associations

• mitochondrial DNA depletion syndrome 1 MONDO:0011283

Drugs targeting this protein · 1

• TIPIRACIL HYDROCHLORIDE inhibitor

Related proteins · sequence + function similarity

• Thymidine phosphorylase 0.95
• Thymidine phosphorylase 0.95
• Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0.70
• Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0.70
• Glycerate kinase 0.70
• Nicotinate phosphoribosyltransferase 0.69
• Glycerate kinase 0.69
• Carnosine synthase 1 0.68
• Nicotinate phosphoribosyltransferase 0.68
• Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0.68
• Glycerate kinase 0.67
• Nicotinate phosphoribosyltransferase 0.67

Literature · 14 cited papers

• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Structures of native human thymidine phosphorylase and in complex with 5-iodouracil. Biochem. Biophys. Res. Commun. · 2009
• Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implications for drug design. Biochem. J. · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor. Structure · 2004
• Phenotypic variability in a Spanish family with MNGIE. Neurology · 2002
• The DNA sequence of human chromosome 22. Nature · 1999
• Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. Science · 1999
• Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature · 1989
• Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Biochem. Biophys. Res. Commun. · 1992
• Expression of recombinant platelet-derived endothelial cell growth factor in the yeast Saccharomyces cerevisiae. Yeast · 1992
• … and 2 more in the literature graph