Genome polyprotein

UniProt P19712 Organism Classical swine fever virus (strain Alfort/Tuebingen) EC 3.4.22.-, 3.4.21.113, 3.6.1.15, 3.6.4.13, 2.7.7.48

Function

Leader cysteine autoprotease that cleaves itself from the nascent polyprotein during translation of the viral mRNA. Once released, plays a role in the inhibition of host innate immune response by interacting with host IRF3 and inducing its proteasomal degradation.

Classification

Family (Pfam): PF11889 Capsid_pestivir, PF20907 Flav_NS3-hel_C, PF07652 Flavi_DEAD, PF00271 Helicase_C, PF05550 Peptidase_C53, PF12387 Peptidase_C74, PF05578 Peptidase_S31, PF16329 Pestivirus_E2, PF00998 RdRP_3
InterPro: Capsid-C_pestivirus, DNA/RNA_pol_sf, Flavi_DEAD, Helicase_ATP-bd, Helicase_C-like, NS2, NS2_C74, NS3-hel_C_flaviviridae, P-loop_NTPase, Peptidase_C53, Peptidase_C53_interaction, Pestivirus_E2, Pestivirus_E2_A, Pestivirus_E2_B, Pestivirus_E2_D, Pestivirus_NS3_S31, Rev_trsase/Diguanyl_cyclase, RNA-dir_pol_PSvirus, RNA_pol_HCV, RNase_T2-like_sf, RNase_T2_His_AS_2
Functional cluster: Viral Structural & Replication Proteins

Experimental structures · PDB · 6

4CBG X-ray 2.82A
4CBH X-ray 2.51A
4CBI X-ray 3.00A
4CBL X-ray 3.05A
4CBM X-ray 3.27A
5MZ4 X-ray 3.05A

A predicted model is available from AlphaFold.

Gene Ontology · 24

Neighborhood · nearest proteins

Nearest neighbours of Genome polyprotein: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Genome polyprotein 0.98
Genome polyprotein 0.96
Genome polyprotein 0.94
Genome polyprotein 0.93
Genome polyprotein 0.80
Structural polyprotein 0.77
Structural polyprotein 0.76
Frameshifted structural polyprotein 0.76
Structural polyprotein 0.75
Structural polyprotein 0.75
Structural polyprotein 0.75
Structural polyprotein 0.75

Co-cited proteins · studied together in the literature

Genome polyprotein 1 shared papers
Disintegrin and metalloproteinase domain-containing protein 17 1 shared papers
Genome polyprotein 1 shared papers
Genome polyprotein 1 shared papers
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 1 shared papers
Ferritin heavy chain 1 shared papers

Literature · 39 cited papers

N-terminal domain of classical swine fever virus Npro induces proteasomal degradation of specificity protein 1 with reduced HDAC1 expression to evade from innate immune responses. J. Virol. · 2023
ADAM17 is an essential attachment factor for classical swine fever virus. PLoS Pathog. · 2021
Viperin inhibits classical swine fever virus replication by interacting with viral nonstructural 5A protein. J. Med. Virol. · 2020
FHC, an NS4B-interacting Protein, Enhances Classical Swine Fever Virus Propagation and Acts Positively in Viral Anti-apoptosis. Sci. Rep. · 2018
dimerization via pseudoreversion partially restores virulence of classical swine fever virus. J. Gen. Virol. · 2018
Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex. Front. Microbiol. · 2017
TRAF6 is a novel NS3-interacting protein that inhibits classical swine fever virus replication. Sci. Rep. · 2017
The core protein of a pestivirus protects the incoming virus against IFN-induced effectors. Sci. Rep. · 2017
A positive-strand RNA virus uses alternative protein-protein interactions within a viral protease/cofactor complex to switch between RNA replication and virion morphogenesis. PLoS Pathog. · 2017
Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. J. Virol. · 2016
Thioredoxin 2 Is a Novel E2-Interacting Protein That Inhibits the Replication of Classical Swine Fever Virus. J. Virol. · 2015
The laminin receptor is a cellular attachment receptor for classical Swine Fever virus. J. Virol. · 2015
… and 27 more in the literature graph

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