Large ribosomal subunit protein eL33

Function

Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.

Classification

Family (Pfam)

PF01247 Ribosomal_L35Ae

InterPro

Ribosomal_eL33, Ribosomal_eL33_CS, Ribosomal_eL33_sf, Transl_B-barrel_sf

Functional cluster

Ribosomal Proteins & RNA-Processing Enzymes

Experimental structures · PDB · 155

• 4UG0 EM
• 4V6X EM 5.00A
• 5AJ0 EM 3.50A
• 5LKS EM 3.60A
• 5T2C EM 3.60A
• 6IP5 EM 3.90A
• 6IP6 EM 4.50A
• 6IP8 EM 3.90A
• 6LQM EM 3.09A
• 6LSR EM 3.13A
• 6LSS EM 3.23A
• 6LU8 EM 3.13A
• … and 143 more

A predicted model is available from AlphaFold.

Gene Ontology · 17

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0070062 extracellular exosome
• GO:0016020 membrane
• GO:0045202 synapse
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0000049 tRNA binding
• GO:0002181 cytoplasmic translation
• GO:1901740 negative regulation of myoblast fusion
• GO:0042273 ribosomal large subunit biogenesis
• GO:0006364 rRNA processing
• GO:0007283 spermatogenesis
• GO:0006941 striated muscle contraction
• GO:0006412 translation

Disease associations

• Diamond-Blackfan anemia 5 MONDO:0012925

Drugs targeting this protein · 2

• CYCLOHEXIMIDE inhibitor
• ATALUREN modulator

Related proteins · sequence + function similarity

• Large ribosomal subunit protein eL33 1.00
• Large ribosomal subunit protein eL33 1.00
• Large ribosomal subunit protein eL33 1.00
• Large ribosomal subunit protein eL33 1.00
• Large ribosomal subunit protein eL33 1.00
• Large ribosomal subunit protein eL33 1.00
• Large ribosomal subunit protein eL33 0.99
• Large ribosomal subunit protein eL33 0.96
• Large ribosomal subunit protein eL33 0.93
• Large ribosomal subunit protein eL33A 0.92
• Large ribosomal subunit protein eL33z 0.92
• Large ribosomal subunit protein eL33B 0.92

Literature · 10 cited papers

• Structural snapshots of human pre-60S ribosomal particles before and after nuclear export. Nat. Commun. · 2020
• N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
• A new system for naming ribosomal proteins. Curr. Opin. Struct. Biol. · 2014
• Structures of the human and Drosophila 80S ribosome. Nature · 2013
• Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
• Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
• Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Blood · 2008
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter. Genomics · 1996
• cDNA encoding the human homologue of rat ribosomal protein L35a. Nucleic Acids Res. · 1990