Tripartite terminase subunit 2

Function

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid.

Classification

Family (Pfam)

PF03581 Herpes_UL33

InterPro

Herpes_TT2

Functional cluster

Viral Structural & Replication Proteins

Gene Ontology · 2

• GO:0042025 host cell nucleus
• GO:0019073 viral DNA genome packaging

Drugs targeting this protein · 1

• LETERMOVIR inhibitor

Related proteins · sequence + function similarity

• Tripartite terminase subunit 2 1.00
• Autophagy-related protein 31 0.66
• Protein Vpu 0.60
• COP9 signalosome complex subunit 9 0.60
• COP9 signalosome complex subunit 9 0.60
• DNA-directed RNA polymerases I, II, and III subunit RPABC2 0.60
• COP9 signalosome complex subunit 9 0.59
• COP9 signalosome complex subunit 9 0.59
• COP9 signalosome complex subunit 9 0.59
• Tumor rejection antigen P815A 0.58
• Uncharacterized protein AF_2230 0.58
• Protein Vpu 0.58

Co-cited proteins · studied together in the literature

• Uncharacterized protein UL49 1 shared papers
• Packaging protein UL32 homolog 1 shared papers
• DNA polymerase catalytic subunit 1 shared papers
• Envelope glycoprotein B 1 shared papers
• Nuclear egress protein 2 1 shared papers
• Nuclear egress protein 1 1 shared papers

Literature · 4 cited papers

• Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J. Virol. · 2004
• The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J. Gen. Virol. · 2003
• Large-scale rearrangement of homologous regions in the genomes of HCMV and EBV. Virology · 1987
• Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. · 1990