Tripartite terminase subunit 3
Also known as: TRM3, UL89
Function
Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM1 and TRM2 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM3 carries an RNase H-like nuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.
Classification
- Family (Pfam)
- PF02499 DNA_pack_C, PF02500 DNA_pack_N
- InterPro
- DNA_pack_C, DNA_pack_C_sf, DNA_pack_N, HSV_TRM3, P-loop_NTPase
- Functional cluster
- Phosphoribosyltransferases & related
Experimental structures · PDB · 3
A predicted model is available from AlphaFold.
Gene Ontology · 4
Drugs targeting this protein · 1
- LETERMOVIR inhibitor
Related proteins · sequence + function similarity
- Tripartite terminase subunit 3 1.00
- Tripartite terminase subunit 3 0.89
- Tripartite terminase subunit 3 0.89
- Tripartite terminase subunit 3 0.88
- Tripartite terminase subunit 3 0.87
- Tripartite terminase subunit 3 0.87
- Tripartite terminase subunit 3 0.87
- Tripartite terminase subunit 3 0.87
- Tripartite terminase subunit 3 0.86
- Tripartite terminase subunit 3 0.86
- Tripartite terminase subunit 3 0.82
- Tripartite terminase subunit 3 0.82
Literature · 5 cited papers
- Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain. Proc. Natl. Acad. Sci. U.S.A. · 2010
- Identification of the interaction domain of the small terminase subunit pUL89 with the large subunit pUL56 of human cytomegalovirus. Biochemistry · 2006
- Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome. J. Virol. · 2004
- The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J. Gen. Virol. · 2003
- Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. · 1990
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