Tripartite terminase subunit 1

Function

Component of the molecular motor that translocates viral genomic DNA in empty capsid during DNA packaging. Forms a tripartite terminase complex together with TRM2 and TRM3 in the host cytoplasm. Once the complex reaches the host nucleus, it interacts with the capsid portal vertex. This portal forms a ring in which genomic DNA is translocated into the capsid. TRM1 carries an endonuclease activity that plays an important role for the cleavage of concatemeric viral DNA into unit length genomes.

Classification

Family (Pfam)

PF01366 PRTP

InterPro

UL28/UL56

Functional cluster

Viral Structural & Replication Proteins

Gene Ontology · 4

• GO:0042025 host cell nucleus
• GO:0005524 ATP binding
• GO:0008270 zinc ion binding
• GO:0019073 viral DNA genome packaging

Drugs targeting this protein · 1

• LETERMOVIR inhibitor

Related proteins · sequence + function similarity

• Tripartite terminase subunit 1 1.00
• Tripartite terminase subunit 1 0.88
• Tripartite terminase subunit 1 0.88
• Uncharacterized protein UL87 0.82
• Protein UL87 0.82
• Inner tegument protein 0.81
• Inner tegument protein 0.80
• Portal protein 0.80
• Portal protein 0.80
• Capsid vertex component 2 0.79
• Major capsid protein 0.77
• Major capsid protein 0.77

Literature · 2 cited papers

• The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J. Gen. Virol. · 2003
• Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr. Top. Microbiol. Immunol. · 1990