Dipeptidase 1

Function

Hydrolyzes a wide range of dipeptides including the conversion of leukotriene D4 to leukotriene E4. Hydrolyzes cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation. Also possesses beta lactamase activity and can hydrolyze the beta-lactam antibiotic imipenem.

Classification

Family (Pfam)

PF01244 Peptidase_M19

InterPro

Dipep_AS, Metal_Hydrolase, Pept_M19

Functional cluster

Secreted Growth Factors & Cytokines

Experimental structures · PDB · 2

• 1ITQ X-ray 2.30A
• 1ITU X-ray 2.00A

A predicted model is available from AlphaFold.

Gene Ontology · 27

• GO:0045177 apical part of cell
• GO:0016324 apical plasma membrane
• GO:0030054 cell junction
• GO:0070062 extracellular exosome
• GO:0005615 extracellular space
• GO:0031528 microvillus membrane
• GO:0005886 plasma membrane
• GO:0098552 side of membrane
• GO:0008800 beta-lactamase activity
• GO:0016805 dipeptidase activity
• GO:0034235 GPI anchor binding
• GO:0070573 metallodipeptidase activity
• GO:0008235 metalloexopeptidase activity
• GO:0072341 modified amino acid binding
• GO:0008270 zinc ion binding
• GO:0016999 antibiotic metabolic process
• GO:0071277 cellular response to calcium ion
• GO:0071732 cellular response to nitric oxide
• GO:0006751 glutathione catabolic process
• GO:0006749 glutathione metabolic process
• GO:0050667 homocysteine metabolic process
• GO:0006954 inflammatory response
• GO:0072340 lactam catabolic process
• GO:1901749 leukotriene D4 catabolic process
• GO:0030336 negative regulation of cell migration
• GO:0030593 neutrophil chemotaxis
• GO:0006508 proteolysis

Drugs targeting this protein · 2

• CILASTATIN SODIUM inhibitor
• CILASTATIN inhibitor

Related proteins · sequence + function similarity

• Dipeptidase 1 0.97
• Dipeptidase 1 0.96
• Dipeptidase 1 0.94
• Dipeptidase 1 0.93
• Dipeptidase 1 0.92
• Dipeptidase 1 0.90
• Dipeptidase 2 0.86
• Dipeptidase 2 0.85
• Dipeptidase 2 0.85
• Dipeptidase 3 0.81
• Dipeptidase 3 0.81
• Dipeptidase 3 0.80

Co-cited proteins · studied together in the literature

• Dipeptidase 1 1 shared papers
• Dipeptidase 1 1 shared papers
• Dipeptidase 2 1 shared papers
• Dipeptidase 3 1 shared papers
• Dipeptidase 3 1 shared papers

Literature · 16 cited papers

• Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity. J. Struct. Biol. · 2020
• Dipeptidase-1 is an adhesion receptor for neutrophil recruitment in lungs and liver. Cell · 2019
• Clinicopathological examination of dipeptidase 1 expression in colorectal cancer. Biomed. Rep. · 2017
• Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J. Proteome Res. · 2009
• The consensus coding sequences of human breast and colorectal cancers. Science · 2006
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Signal peptide prediction based on analysis of experimentally verified cleavage sites. Protein Sci. · 2004
• Crystal structure of human renal dipeptidase involved in beta-lactam hydrolysis. J. Mol. Biol. · 2002
• Cloning and structural analysis of genomic DNA for human renal dipeptidase. Biochim. Biophys. Acta · 1993
• Importance of Glu-125 in the catalytic activity of human renal dipeptidase. Biochim. Biophys. Acta · 1993
• Gene structural analysis and expression of human renal dipeptidase. Biotechnol. Prog. · 1994
• Beta-lactamase activity of purified and partially characterized human renal dipeptidase. J. Biol. Chem. · 1984
• … and 4 more in the literature graph