Pancreatic triacylglycerol lipase

Function

Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.

Classification

Family (Pfam)

PF00151 Lipase, PF01477 PLAT

InterPro

AB_hydrolase_fold, Lipase, Lipase_LIPH, Lipase_N, Lipase_panc, PLAT/LH2_dom, PLAT/LH2_dom_sf, TAG_lipase

Functional cluster

Secreted Hydrolases & Toxins

Experimental structures · PDB · 4

• 1GPL X-ray 2.01A
• 1LPA X-ray 3.04A
• 1LPB X-ray 2.46A
• 1N8S X-ray 3.04A

A predicted model is available from AlphaFold.

Gene Ontology · 14

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
• GO:0008970 glycerophospholipid phospholipase A1 activity
• GO:0016298 lipase activity
• GO:0004465 lipoprotein lipase activity
• GO:0046872 metal ion binding
• GO:0004806 triacylglycerol lipase activity
• GO:0042632 cholesterol homeostasis
• GO:0006633 fatty acid biosynthetic process
• GO:0034375 high-density lipoprotein particle remodeling
• GO:0006629 lipid metabolic process
• GO:0061365 positive regulation of triglyceride lipase activity
• GO:0019433 triglyceride catabolic process

Disease associations

• pancreatic triacylglycerol lipase deficiency MONDO:0013700

Drugs targeting this protein · 2

• ORLISTAT inhibitor
• CETILISTAT inhibitor

Related proteins · sequence + function similarity

• Pancreatic triacylglycerol lipase 0.98
• Pancreatic triacylglycerol lipase 0.97
• Pancreatic triacylglycerol lipase 0.97
• Pancreatic triacylglycerol lipase 0.97
• Inactive pancreatic lipase-related protein 1 0.96
• Pancreatic triacylglycerol lipase 0.96
• Inactive pancreatic lipase-related protein 1 0.96
• Inactive pancreatic lipase-related protein 1 0.96
• Pancreatic triacylglycerol lipase 0.96
• Pancreatic lipase-related protein 2 0.96
• Pancreatic triacylglycerol lipase 0.96
• Pancreatic lipase-related protein 2 0.95

Co-cited proteins · studied together in the literature

• Colipase 2 shared papers
• Colipase 3 shared papers
• Pancreatic lipase-related protein 2 3 shared papers
• Inactive pancreatic lipase-related protein 1 1 shared papers
• Pancreatic triacylglycerol lipase 1 shared papers
• Colipase 1 shared papers
• Pancreatic lipase-related protein 2 1 shared papers
• Pancreatic triacylglycerol lipase 1 shared papers

Literature · 16 cited papers

• The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2). J. Biol. Chem. · 2015
• A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding. Biochim. Biophys. Acta · 2015
• Identification of a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency. J. Lipid Res. · 2014
• Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells. J. Lipid Res. · 2007
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• The DNA sequence and comparative analysis of human chromosome 10. Nature · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Hydrolysis of retinyl esters by pancreatic triglyceride lipase. Biochemistry · 2000
• Interfacial activation of the lipase-procolipase complex by mixed micelles revealed by X-ray crystallography. Nature · 1993
• The human pancreatic lipase-encoding gene: structure and conservation of an Alu sequence in the lipase gene family. Gene · 1993
• Structure-function relationships in naturally occurring mutants of pancreatic lipase. Protein Eng. · 1994
• The 2.46 A resolution structure of the pancreatic lipase-colipase complex inhibited by a C11 alkyl phosphonate. Biochemistry · 1995
• … and 4 more in the literature graph