Dihydrofolate reductase
Function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Classification
- Family (Pfam)
- PF00186 DHFR_1
- InterPro
- DHFR, DHFR-like_dom_sf, DHFR_CS, DHFR_dom
- Functional cluster
- Zinc-Finger Nucleic-Acid-Binding & Methyltransferases
Experimental structures · PDB · 25
- 1CD2 X-ray 2.20A
- 1DAJ X-ray 2.30A
- 1DYR X-ray 1.86A
- 1E26 X-ray 2.00A
- 1KLK X-ray 2.30A
- 1LY3 X-ray 1.90A
- 1LY4 X-ray 2.10A
- 1S3Y X-ray 2.25A
- 1VJ3 X-ray 2.10A
- 2CD2 X-ray 1.90A
- 2FZH X-ray 2.10A
- 2FZI X-ray 1.60A
- … and 13 more
A predicted model is available from AlphaFold.
Gene Ontology · 7
Drugs targeting this protein · 1
- TRIMETREXATE GLUCURONATE inhibitor
Related proteins · sequence + function similarity
- Dihydrofolate reductase 0.86
- Dihydrofolate reductase 0.79
- Dihydrofolate reductase 0.74
- Dihydrofolate reductase 0.73
- Dihydrofolate reductase 0.73
- Putative dihydrofolate reductase 0.72
- Dihydrofolate reductase 0.71
- Viral dihydrofolate reductase 0.69
- 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase 0.69
- Dihydrofolate reductase 0.69
- 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase 0.69
- Viral dihydrofolate reductase 0.68
Co-cited proteins · studied together in the literature
- Dihydrofolate reductase 1 shared papers
- Dihydrofolate reductase 1 shared papers
Literature · 8 cited papers
- New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions. Proteins · 2006
- Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr. D · 2004
- Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr. D · 2002
- Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Acta Crystallogr. D · 2002
- Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate. Biochemistry · 2000
- Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+. Biochemistry · 1999
- The structure of Pneumocystis carinii dihydrofolate reductase to 1.9-A resolution. Structure · 1994
- Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene. Proc. Natl. Acad. Sci. U.S.A. · 1989
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