Ankyrin-1

UniProt P16157 Organism Homo sapiens Gene ANK, ANK1

Also known as: ANK, ANK1

Function

Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions.

Classification

Family (Pfam): PF00023 Ank, PF12796 Ank_2, PF13637 Ank_4, PF00531 Death, PF17809 UPA_2, PF00791 ZU5
InterPro: Ankyrin_rpt, Ankyrin_rpt-contain_sf, Ankyrin_UPA, DEATH-like_dom_sf, Death_dom, Multifunctional_ANK_Repeat, ZU5_dom
Functional cluster: C2H2 Zinc-Finger Transcription Factors

Experimental structures · PDB · 21

1N11 X-ray 2.70A
2YQF NMR
2YVI X-ray 1.92A
3F59 X-ray 2.00A
3KBT X-ray 2.75A
3KBU X-ray 2.75A
3UD1 X-ray 2.00A
3UD2 X-ray 2.21A
7TW3 EM 4.40A
7TW5 EM 5.70A
7TW6 EM 5.60A
7UZQ EM 2.17A
… and 9 more

A predicted model is available from AlphaFold.

Gene Ontology · 28

Disease associations

hereditary spherocytosis type 1 MONDO:0008447

Neighborhood · nearest proteins

Nearest neighbours of Ankyrin-1: 3 by sequence/function similarity (left); 3 co-cited in the literature (right).

Related proteins · sequence + function similarity

Ankyrin-1 1.00
Ankyrin-2 0.97
Ankyrin-2 0.96
Ankyrin-3 0.94
Ankyrin-3 0.94
Ankyrin-3 0.93
CARD- and ANK-domain containing inflammasome adapter protein 0.85
Ankyrin repeat protein ftmI 0.79
Ankyrin repeat protein ftmI 0.79
Poly [ADP-ribose] polymerase tankyrase-2 0.78
Poly [ADP-ribose] polymerase tankyrase-2 0.78
Poly [ADP-ribose] polymerase tankyrase 0.77

Co-cited proteins · studied together in the literature

Band 3 anion transport protein 3 shared papers
ATP-sensitive inward rectifier potassium channel 12 1 shared papers
Ankyrin-1 1 shared papers
Obscurin 1 shared papers
Titin 1 shared papers
Serine-repeat antigen protein 6 1 shared papers
Hypoxia-inducible factor 1-alpha inhibitor 1 shared papers
Protein 4.2 1 shared papers
Spectrin beta chain, erythrocytic 1 shared papers
Subtilisin-like protease 1 1 shared papers
Aquaporin-1 1 shared papers
Glycophorin-B 1 shared papers

Literature · 23 cited papers

Architecture of the human erythrocyte ankyrin-1 complex. Nat. Struct. Mol. Biol. · 2022
A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells. Nat. Microbiol. · 2018
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Structurally similar but functionally diverse ZU5 domains in human erythrocyte ankyrin. J. Mol. Biol. · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor. J. Biol. Chem. · 2011
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
Phosphoproteome of resting human platelets. J. Proteome Res. · 2008
The consensus coding sequences of human breast and colorectal cancers. Science · 2006
DNA sequence and analysis of human chromosome 8. Nature · 2006
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
… and 11 more in the literature graph

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