lmmol · Proteins

NAD(P)H dehydrogenase [quinone] 1

UniProt P15559 Organism Homo sapiens Gene DIA4, NMOR1, NQO1 EC 1.6.5.2

Also known as: DIA4, NMOR1, NQO1

Function

Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion. Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential. Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome.

Classification

Family (Pfam)
PF02525 Flavodoxin_2
InterPro
Flavodoxin_fold, Flavoprotein-like_sf, NAD(P)H_dehydrogenase_qn
Functional cluster
Nucleotide & Amino-Acid Biosynthesis Enzymes

Experimental structures · PDB · 27

A predicted model is available from AlphaFold.

Gene Ontology · 27

Drugs targeting this protein · 1

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 21 cited papers

A document in the lmmol reference corpus — open public data (UniProt, GO, PDB, the literature graph) rendered as a single cross-linked page. Hover any link to preview its target.