lmmol · Proteins

Aldo-keto reductase family 1 member B1

UniProt P15121 Organism Homo sapiens Gene AKR1B1, ALDR1, ALR2 EC 1.1.1.21, 1.1.1.300, 1.1.1.372, 1.1.1.54

Also known as: AKR1B1, ALDR1, ALR2

Function

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates. It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose. This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).

Classification

Family (Pfam)
PF00248 Aldo_ket_red
InterPro
AKR, Aldo/ket_reductase_CS, NAD(P)_OxRdtase_dom_sf, NADP_OxRdtase_dom
Functional cluster
Cytochrome P450 & Heme Enzymes

Experimental structures · PDB · 177

A predicted model is available from AlphaFold.

Gene Ontology · 22

Drugs targeting this protein · 4

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 40 cited papers

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