POU domain, class 2, transcription factor 1
Also known as: OCT1, OTF1, POU2F1
Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.
Classification
- Family (Pfam)
- PF00046 Homeodomain, PF00157 Pou, PF19536 POU2F1_C
- InterPro
- HD, Homeobox_CS, Homeodomain-like_sf, Lambda_DNA-bd_dom_sf, POU, POU2F1_C, POU_dom, POU_domain_TF, TF_octamer
- Functional cluster
- RNA-Polymerase II Transcription Factors
Experimental structures · PDB · 8
- 1CQT X-ray 3.20A
- 1E3O X-ray 1.90A
- 1GT0 X-ray 2.60A
- 1HF0 X-ray 2.70A
- 1O4X NMR
- 1OCT X-ray 3.00A
- 1POG NMR
- 1POU NMR
A predicted model is available from AlphaFold.
Gene Ontology · 16
- GO:0000785 chromatin
- GO:0005654 nucleoplasm
- GO:0005634 nucleus
- GO:0090575 RNA polymerase II transcription regulator complex
- GO:0003677 DNA binding
- GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
- GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
- GO:0042802 identical protein binding
- GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
- GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
- GO:0043565 sequence-specific DNA binding
- GO:0006351 DNA-templated transcription
- GO:0045892 negative regulation of DNA-templated transcription
- GO:1902895 positive regulation of miRNA transcription
- GO:0045944 positive regulation of transcription by RNA polymerase II
- GO:0006357 regulation of transcription by RNA polymerase II
Neighborhood · nearest proteins
Related proteins · sequence + function similarity
- POU domain, class 2, transcription factor 1 1.00
- POU domain, class 2, transcription factor 1 1.00
- POU domain, class 2, transcription factor 1 1.00
- POU domain, class 2, transcription factor 1 0.99
- POU domain, class 2, transcription factor 1 0.99
- POU domain, class 2, transcription factor 1 0.99
- Transcription factor Sp4 0.86
- Transcription factor Sp4 0.86
- Polyhomeotic-proximal chromatin protein 0.85
- Zinc finger protein jing homolog 0.84
- Sex determination protein fox-1 0.82
- Transcription factor Sp3 0.82
Co-cited proteins · studied together in the literature
- POU domain, class 2, transcription factor 2 2 shared papers
- Replication and transcription activator 1 shared papers
- Tegument protein VP16 1 shared papers
- POU domain class 2-associating factor 1 1 shared papers
- Glucocorticoid receptor 1 shared papers
- Cyclic AMP-responsive element-binding protein 3 1 shared papers
- DNA-dependent protein kinase catalytic subunit 1 shared papers
- Host cell factor 1 1 shared papers
Literature · 25 cited papers
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
- A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
- Direct interactions of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 ORF50/Rta protein with the cellular protein octamer-1 and DNA are critical for specifying transactivation of a delayed-early promoter and stimulating viral reactivation. J. Virol. · 2007
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat. Biotechnol. · 2006
- The consensus coding sequences of human breast and colorectal cancers. Science · 2006
- The DNA sequence and biological annotation of human chromosome 1. Nature · 2006
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
- … and 13 more in the literature graph
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