Penicillin-binding protein 2x

Function

A transpeptidase that forms peptide cross-links between adjacent glycan strands in cell wall peptidoglycan (PG). Part of the divisome machinery that synthesizes the septal cross wall. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.

Classification

Family (Pfam)

PF03793 PASTA, PF03717 PBP_dimer, PF00905 Transpeptidase

InterPro

Beta-lactam/transpept, Beta-lactam/transpept-like, PASTA_dom, PBP_dimer, PBP_dimer_sf, PbpX, PCN-bd_Tpept

Functional cluster

Cell-Surface & Secreted Bacterial Proteins

Experimental structures · PDB · 8

• 1PMD X-ray 3.50A
• 1QME X-ray 2.40A
• 1QMF X-ray 2.80A
• 1RP5 X-ray 3.00A
• 2Z2L X-ray 2.85A
• 2Z2M X-ray 2.60A
• 2ZC3 X-ray 2.50A
• 2ZC4 X-ray 2.80A

A predicted model is available from AlphaFold.

Gene Ontology · 7

• GO:0005886 plasma membrane
• GO:0008658 penicillin binding
• GO:0051301 cell division
• GO:0071555 cell wall organization
• GO:0009252 peptidoglycan biosynthetic process
• GO:0008360 regulation of cell shape
• GO:0046677 response to antibiotic

Drugs targeting this protein · 1

• CEFTAROLINE FOSAMIL inhibitor

Related proteins · sequence + function similarity

• Penicillin-binding protein 2B 0.92
• Penicillin-binding protein 2B 0.92
• Penicillin-binding protein 2B 0.92
• Penicillin-binding protein 2B 0.92
• Penicillin-binding protein H 0.88
• Penicillin-binding protein 2A 0.88
• Penicillin-binding protein 2a 0.84
• Penicillin-binding protein 2a 0.84
• Penicillin-binding protein 1A 0.83
• Penicillin-binding protein 1A 0.82
• Penicillin-binding protein 1A 0.82
• Penicillin-binding protein 1A 0.79

Literature · 2 cited papers

• Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science · 2001
• X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme. Nat. Struct. Biol. · 1996