Macrophage migration inhibitory factor

UniProt P14174 Organism Homo sapiens Gene GLIF, MIF, MMIF EC 5.3.2.1, 5.3.3.12

Also known as: GLIF, MIF, MMIF

Function

Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.

Classification

Family (Pfam): PF01187 MIF
InterPro: Macrophage_inhib_fac, Macrophage_inhib_fac_CS, Tautomerase/MIF_sf
Functional cluster: Viral Structural & Replication Proteins

Experimental structures · PDB · 118

1CA7 X-ray 2.50A
1CGQ X-ray 2.00A
1GCZ X-ray 1.90A
1GD0 X-ray 1.50A
1GIF X-ray 1.90A
1LJT X-ray 2.00A
1MIF X-ray 2.60A
1P1G X-ray 2.50A
2OOH X-ray 1.85A
2OOW X-ray 1.75A
2OOZ X-ray 1.80A
3B9S X-ray 1.80A
… and 106 more

A predicted model is available from AlphaFold.

Gene Ontology · 47

Disease associations

juvenile idiopathic arthritis MONDO:0011429

Drugs targeting this protein · 1

IGURATIMOD inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Macrophage migration inhibitory factor 4 shared papers
General vesicular transport factor p115 1 shared papers
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein 1 shared papers
Macrophage migration inhibitory factor homolog 1 shared papers
Macrophage migration inhibitory factor 1 shared papers
Macrophage migration inhibitory factor homolog 1 shared papers
HLA class II histocompatibility antigen gamma chain 1 shared papers
COP9 signalosome complex subunit 5 1 shared papers
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1 shared papers
Short-chain specific acyl-CoA dehydrogenase, mitochondrial 1 shared papers
UMP-CMP kinase 1 shared papers
D-dopachrome decarboxylase 1 shared papers

Literature · 33 cited papers

N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations. Proc. Natl. Acad. Sci. U.S.A. · 2013
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
The Golgi-associated protein p115 mediates the secretion of macrophage migration inhibitory factor. J. Immunol. · 2009
Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions. Biochemistry · 2009
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J. Biol. Chem. · 2007
Association between high levels of blood macrophage migration inhibitory factor, inappropriate adrenal response, and early death in patients with severe sepsis. Clin. Infect. Dis. · 2007
Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages. Infect. Immun. · 2005
… and 21 more in the literature graph

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