Inosine-5'-monophosphate dehydrogenase 2

UniProt P12268 Organism Homo sapiens Gene IMPD2, IMPDH2 EC 1.1.1.205

Also known as: IMPD2, IMPDH2

Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Classification

Family (Pfam): PF00571 CBS, PF00478 IMPDH
InterPro: Aldolase_TIM, CBS_dom, IMP_DH, IMP_DH/GMP_Rdtase_CS, IMP_DH_GMPRt
Functional cluster: RuBisCO & Carbon-Fixation Enzymes

Experimental structures · PDB · 25

1B3O X-ray 2.90A
1NF7 X-ray 2.65A
1NFB X-ray 2.90A
6I0M X-ray 2.57A
6I0O X-ray 2.62A
6U8E EM 3.03A
6U8N EM 3.29A
6U8R EM 3.91A
6U8S EM 3.14A
6U9O EM 3.36A
6UA2 EM 4.20A
6UA4 EM 3.65A
… and 13 more

A predicted model is available from AlphaFold.

Gene Ontology · 18

Disease associations

OMIM:617995 RAW:OMIM_617995

Drugs targeting this protein · 7

MYCOPHENOLATE MOFETIL HYDROCHLORIDE inhibitor
MYCOPHENOLATE MOFETIL inhibitor
MYCOPHENOLATE SODIUM inhibitor
MIZORIBINE inhibitor
AVN-944 inhibitor
THIOGUANINE inhibitor
MYCOPHENOLIC ACID inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Inosine-5'-monophosphate dehydrogenase 1 4 shared papers
Ankyrin repeat domain-containing protein 9 2 shared papers
Inosine-5'-monophosphate dehydrogenase 2 1 shared papers
Inosine-5'-monophosphate dehydrogenase 1 shared papers
Argininosuccinate synthase 1 shared papers
Argininosuccinate synthase 1 shared papers
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 1 shared papers
Circadian locomoter output cycles protein kaput 1 shared papers
Basic helix-loop-helix ARNT-like protein 1 1 shared papers
Circadian locomoter output cycles protein kaput 1 shared papers
Basic helix-loop-helix ARNT-like protein 1 1 shared papers

Literature · 27 cited papers

ANKRD9 is a metabolically-controlled regulator of IMPDH2 abundance and macro-assembly. J. Biol. Chem. · 2019
ANKRD9 is associated with tumor suppression as a substrate receptor subunit of ubiquitin ligase. Biochim. Biophys. Acta · 2018
CLOCK acetylates ASS1 to drive circadian rhythm of ureagenesis. Mol. Cell · 2017
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. Nat. Struct. Mol. Biol. · 2017
N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
Glutamine deprivation initiates reversible assembly of mammalian rods and rings. Cell. Mol. Life Sci. · 2014
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal. Chem. · 2009
… and 15 more in the literature graph

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