Ornithine decarboxylase

UniProt P11926 Organism Homo sapiens Gene ODC1 EC 4.1.1.17

Also known as: ODC1

Function

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

Classification

Family (Pfam): PF02784 Orn_Arg_deC_N, PF00278 Orn_DAP_Arg_deC
InterPro: Ala_racemase/Decarboxylase_C, De-COase2_C, De-COase2_CS, De-COase2_N, De-COase2_pyr-phos_BS, Orn/DAP/Arg_de-COase, Orn_de-COase, PLP-binding_barrel
Functional cluster: Nucleotide & Amino-Acid Biosynthesis Enzymes

Experimental structures · PDB · 11

1D7K X-ray 2.10A
2ON3 X-ray 3.00A
2OO0 X-ray 1.90A
4ZGY X-ray 2.63A
5BWA X-ray 3.20A
7S3F X-ray 2.49A
7S3G X-ray 1.66A
7U6P X-ray 2.35A
7U6U X-ray 1.85A
9B8M X-ray 2.90A
9B8N X-ray 2.00A

A predicted model is available from AlphaFold.

Gene Ontology · 11

Disease associations

neurodevelopmental disorder with alopecia and brain abnormalities MONDO:0033642

Drugs targeting this protein · 1

EFLORNITHINE HYDROCHLORIDE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Ornithine decarboxylase 1 shared papers
Ornithine decarboxylase antizyme 1 3 shared papers
Antizyme inhibitor 1 2 shared papers
Ornithine decarboxylase antizyme 2 1 shared papers
Ornithine decarboxylase antizyme 3 1 shared papers
Antizyme inhibitor 2 1 shared papers
Serine/threonine-protein kinase DCLK1 1 shared papers
AP-1 complex subunit sigma-1A 1 shared papers
Elongation factor 1-gamma 1 shared papers
Serine/threonine-protein kinase pim-2 1 shared papers
Stathmin 1 shared papers
Translationally-controlled tumor protein 1 shared papers

Literature · 22 cited papers

Gain-of-function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities. Am. J. Med. Genet. A · 2018
Novel de novo pathogenic variant in the ODC1 gene in a girl with developmental delay, alopecia, and dysmorphic features. Am. J. Med. Genet. A · 2018
Structural basis of ornithine decarboxylase inactivation and accelerated degradation by polyamine sensor antizyme1. Sci. Rep. · 2015
Structural basis of antizyme-mediated regulation of polyamine homeostasis. Proc. Natl. Acad. Sci. U.S.A. · 2015
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. Biochem. J. · 2008
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane. Biochem. J. · 2007
Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell. Microbiol. · 2006
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature · 2005
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. J. Biol. Chem. · 2001
Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding. J. Mol. Biol. · 2000
… and 10 more in the literature graph

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