Cholesteryl ester transfer protein

Function

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.

Classification

Family (Pfam)

PF01273 LBP_BPI_CETP, PF02886 LBP_BPI_CETP_C

InterPro

Bactericidal_perm-incr_a/b_dom, Cholesteryl_ester_transfer, Lipid-bd_serum_glycop_C, Lipid-bd_serum_glycop_CS, Lipid-bd_serum_glycop_N

Functional cluster

Immunoglobulin & Immune-Response Proteins

Experimental structures · PDB · 3

• 2OBD X-ray 2.10A
• 4EWS X-ray 2.59A
• 4F2A X-ray 3.11A

A predicted model is available from AlphaFold.

Gene Ontology · 29

• GO:0070062 extracellular exosome
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0034364 high-density lipoprotein particle
• GO:0031982 vesicle
• GO:0015485 cholesterol binding
• GO:0120020 cholesterol transfer activity
• GO:0008289 lipid binding
• GO:0031210 phosphatidylcholine binding
• GO:0005548 phospholipid transporter activity
• GO:0017129 triglyceride binding
• GO:0042632 cholesterol homeostasis
• GO:0008203 cholesterol metabolic process
• GO:0030301 cholesterol transport
• GO:0034375 high-density lipoprotein particle remodeling
• GO:0055088 lipid homeostasis
• GO:0006869 lipid transport
• GO:0034374 low-density lipoprotein particle remodeling
• GO:0010745 negative regulation of macrophage derived foam cell differentiation
• GO:0046470 phosphatidylcholine metabolic process
• GO:0055091 phospholipid homeostasis
• GO:0032376 positive regulation of cholesterol transport
• GO:2001140 positive regulation of phospholipid transport
• GO:0010874 regulation of cholesterol efflux
• GO:0043691 reverse cholesterol transport
• GO:0070328 triglyceride homeostasis
• GO:0006641 triglyceride metabolic process
• GO:0034197 triglyceride transport
• GO:0034372 very-low-density lipoprotein particle remodeling

Disease associations

• cholesterol-ester transfer protein deficiency MONDO:0007744

Drugs targeting this protein · 6

• ANACETRAPIB inhibitor
• EVACETRAPIB inhibitor
• DALCETRAPIB inhibitor
• OBICETRAPIB inhibitor
• ROCACETRAPIB inhibitor
• TORCETRAPIB inhibitor

Related proteins · sequence + function similarity

• Cholesteryl ester transfer protein 1.00
• Cholesteryl ester transfer protein 0.98
• Cholesteryl ester transfer protein 0.95
• Cholesteryl ester transfer protein 0.94
• BPI fold-containing family B member 1 0.90
• Phospholipid transfer protein 0.90
• BPI fold-containing family B member 1 0.90
• Phospholipid transfer protein 0.89
• BPI fold-containing family B member 1 0.88
• Cholesteryl ester transfer protein 0.88
• BPI fold-containing family B member 1 0.88
• BPI fold-containing family C protein 0.86

Co-cited proteins · studied together in the literature

• Cholesteryl ester transfer protein 1 shared papers
• Cholesteryl ester transfer protein 1 shared papers
• Cholesteryl ester transfer protein 1 shared papers
• Phospholipid transfer protein 1 shared papers
• Endothelial lipase 1 shared papers
• Hepatic triacylglycerol lipase 1 shared papers
• Phosphatidylcholine-sterol acyltransferase 1 shared papers
• Scavenger receptor class B member 1 1 shared papers
• Phospholipid-transporting ATPase ABCA1 1 shared papers
• Lipoprotein lipase 1 shared papers
• Apolipoprotein E 1 shared papers
• Apolipoprotein A-I 1 shared papers

Literature · 16 cited papers

• Cholesteryl ester transfer proteins from different species do not have equivalent activities. J. Lipid Res. · 2014
• A strategy for precise and large scale identification of core fucosylated glycoproteins. Mol. Cell. Proteomics · 2009
• Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol. Am. J. Hum. Genet. · 2007
• Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat. Struct. Mol. Biol. · 2007
• Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. J. Proteome Res. · 2005
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors. Hum. Mol. Genet. · 2003
• Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay. J. Lipid Res. · 2002
• Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. · 1999
• Sequencing of the cholesteryl ester transfer protein 5' regulatory region using artificial transposons. Gene · 1997
• Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distal sequences. Cis-acting sequences mapped in transgenic mice. J. Biol. Chem. · 1996
• A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins. J. Clin. Invest. · 1993
• … and 4 more in the literature graph