lmmol · Proteins

Breakpoint cluster region protein

UniProt P11274 Organism Homo sapiens Gene BCR, BCR1, D22S11 EC 2.7.11.1

Also known as: BCR, BCR1, D22S11

Function

Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity. Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity. Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation.

Classification

Family (Pfam)
PF09036 Bcr-Abl_Oligo, PF00168 C2, PF19057 PH_19, PF00620 RhoGAP, PF00621 RhoGEF
InterPro
Abr/Bcr, Bcr-Abl_oncoprot_oligo, Bcr-Abl_oncoprot_oligo_sf, C2_dom, C2_domain_sf, DBL_dom_sf, DH_dom, GDS_CDC24_CS, PH-like_dom_sf, PH_domain, Rho_GTPase_activation_prot, RhoGAP_dom
Functional cluster
RNA Polymerase II Transcription Factors

Experimental structures · PDB · 5

A predicted model is available from AlphaFold.

Gene Ontology · 28

Disease associations

Drugs targeting this protein · 10

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 34 cited papers

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