Growth hormone receptor

Function

Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway.

Classification

Family (Pfam)

PF09067 EpoR_lig-bind, PF00041 fn3, PF12772 GHBP

InterPro

FN3_dom, FN3_sf, GHBP, Growth/epo_recpt_lig-bind, Ig-like_fold, Long_hematopoietin_rcpt_CS

Functional cluster

Zinc-Finger & Chromatin Regulatory Proteins

Experimental structures · PDB · 11

• 1A22 X-ray 2.60A
• 1AXI X-ray 2.10A
• 1HWG X-ray 2.50A
• 1HWH X-ray 2.90A
• 1KF9 X-ray 2.60A
• 2AEW X-ray 2.70A
• 3HHR X-ray 2.80A
• 5OEK NMR
• 5OHD NMR
• 6I5J X-ray 2.80A
• 6I5N X-ray 1.98A

A predicted model is available from AlphaFold.

Gene Ontology · 47

• GO:0009986 cell surface
• GO:0005829 cytosol
• GO:0009897 external side of plasma membrane
• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0070195 growth hormone receptor complex
• GO:0016020 membrane
• GO:0043025 neuronal cell body
• GO:0005886 plasma membrane
• GO:0043235 receptor complex
• GO:0019955 cytokine binding
• GO:0019838 growth factor binding
• GO:0004903 growth hormone receptor activity
• GO:0042802 identical protein binding
• GO:0008289 lipid binding
• GO:0017046 peptide hormone binding
• GO:0070064 proline-rich region binding
• GO:0042803 protein homodimerization activity
• GO:0019903 protein phosphatase binding
• GO:0030296 protein tyrosine kinase activator activity
• GO:1990782 protein tyrosine kinase binding
• GO:0042169 SH2 domain binding
• GO:0060351 cartilage development involved in endochondral bone morphogenesis
• GO:0007259 cell surface receptor signaling pathway via JAK-STAT
• GO:0032870 cellular response to hormone stimulus
• GO:0032869 cellular response to insulin stimulus
• GO:0019221 cytokine-mediated signaling pathway
• GO:0006897 endocytosis
• GO:0060396 growth hormone receptor signaling pathway
• GO:0042445 hormone metabolic process
• GO:0009755 hormone-mediated signaling pathway
• GO:0048009 insulin-like growth factor receptor signaling pathway
• GO:0045597 positive regulation of cell differentiation
• GO:0008284 positive regulation of cell population proliferation
• GO:0043410 positive regulation of MAPK cascade
• GO:0040018 positive regulation of multicellular organism growth
• GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT
• GO:0031623 receptor internalization
• GO:0040014 regulation of multicellular organism growth
• GO:0032107 regulation of response to nutrient levels
• GO:0046898 response to cycloheximide
• GO:0032355 response to estradiol
• GO:0032094 response to food
• GO:0051384 response to glucocorticoid
• GO:0009629 response to gravity
• GO:0070555 response to interleukin-1
• GO:0019530 taurine metabolic process

Disease associations

• hypercholesterolemia, familial, 1 MONDO:0007750
• Laron syndrome MONDO:0009877
• short stature due to partial GHR deficiency MONDO:0011420

Drugs targeting this protein · 1

• SOMAPACITAN agonist

Related proteins · sequence + function similarity

• Growth hormone receptor 1.00
• Growth hormone receptor 1.00
• Growth hormone receptor 0.99
• Growth hormone receptor 0.99
• Growth hormone receptor 0.99
• Growth hormone receptor 0.98
• Growth hormone receptor 0.98
• Growth hormone receptor 0.98
• Growth hormone receptor 0.98
• Growth hormone receptor 0.98
• Growth hormone receptor 0.98
• Growth hormone receptor 0.97

Co-cited proteins · studied together in the literature

• Growth hormone receptor 1 shared papers
• Somatotropin 2 shared papers
• Suppressor of cytokine signaling 2 1 shared papers
• Suppressor of cytokine signaling 2 4 shared papers
• Growth hormone receptor 1 shared papers
• Elongin-B 4 shared papers
• Elongin-C 4 shared papers
• Tyrosine-protein kinase JAK2 1 shared papers
• Erythropoietin receptor 1 shared papers
• RING-box protein 2 2 shared papers
• Cullin-5 2 shared papers

Literature · 32 cited papers

• Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. Nat. Commun. · 2021
• Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. Nat. Commun. · 2019
• Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). J. Biol. Chem. · 2015
• An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
• The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels. PLoS ONE · 2011
• SOCS2 negatively regulates growth hormone action in vitro and in vivo. J. Clin. Invest. · 2005
• The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: suppression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration. Clin. Endocrinol. (Oxf.) · 2004
• Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred. Am. J. Med. Genet. A · 2003
• Identification of a region critical for proteolysis of the human growth hormone receptor. Biochem. Biophys. Res. Commun. · 2002
• Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation. Eur. J. Endocrinol. · 2000
• Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution. J. Biol. Chem. · 2000
• Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat. Genet. · 1999
• … and 20 more in the literature graph