lmmol · Proteins

Lanosterol 14-alpha demethylase

UniProt P10613 Organism Candida albicans (strain SC5314 / ATCC MYA-2876) Gene CAALFM_C500660CA, CYP51, ERG11, ERG16 EC 1.14.14.154

Also known as: CAALFM_C500660CA, CYP51, ERG11, ERG16

Function

Sterol 14alpha-demethylase that plays a critical role in the third module of ergosterol biosynthesis pathway, being ergosterol the major sterol component in fungal membranes that participates in a variety of functions. The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane (By similarity). In filamentous fungi, during the initial step of this module, lanosterol (lanosta-8,24-dien-3beta-ol) can be metabolized to eburicol (By similarity). Sterol 14alpha-demethylase catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of both these sterols in the form of formate, and converts eburicol and lanosterol to 14-demethyleburicol (4,4,24-trimethylergosta-8,14,24(28)-trienol) and 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol, respectively, which are further metabolized by other enzymes in the pathway to ergosterol. Can also use substrates not intrinsic to fungi, such as 24,25-dihydrolanosterol (DHL), producing 4,4-dimethyl-8,14-cholestadien-3-beta-ol, but at lower rates than the endogenous substrates (By similarity).

Classification

Family (Pfam)
PF00067 p450
InterPro
CYP450_sterol_14alpha_dmase, Cyt_P450, Cyt_P450_CS, Cyt_P450_E_grp-IV, Cyt_P450_sf
Functional cluster
Oxidoreductases, Catalases & Peroxidases

Experimental structures · PDB · 3

A predicted model is available from AlphaFold.

Gene Ontology · 14

Drugs targeting this protein · 21

Neighborhood · nearest proteins

CAALFM_C500660CACYP51CAGL0E04334gCYP51CYP51
Nearest neighbours of Lanosterol 14-alpha demethylase: 3 by sequence/function similarity (left); 1 co-cited in the literature (right).

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Literature · 23 cited papers

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