Serine/threonine-protein kinase A-Raf

UniProt P10398 Organism Homo sapiens Gene ARAF, ARAF1, PKS, PKS2 EC 2.7.11.1

Also known as: ARAF, ARAF1, PKS, PKS2

Function

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2.

Classification

Family (Pfam): PF00130 C1_1, PF07714 PK_Tyr_Ser-Thr, PF02196 RBD
InterPro: C1-like_sf, DAG/PE-bd, Kinase-like_dom_sf, PKC_DAG/PE, Prot_kinase_dom, Protein_kinase_ATP_BS, RBD_dom, Ser-Thr/Tyr_kinase_cat_dom, Ser/Thr_kinase_AS, Ser/Thr_Kinases-Pseudokinases, Ubiquitin-like_domsf
Functional cluster: Homeobox & Zinc-Finger Transcription Factors

Experimental structures · PDB · 6

1WXM NMR
2MSE NMR
8VSL X-ray 1.42A
8VSM X-ray 1.50A
8VSN X-ray 1.91A
9AXM X-ray 2.42A

A predicted model is available from AlphaFold.

Gene Ontology · 16

Drugs targeting this protein · 3

TOVORAFENIB inhibitor
LY-3009120 inhibitor
BELVARAFENIB inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Negative elongation factor C/D 1 shared papers
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 1 shared papers
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 1 shared papers
E3 ubiquitin-protein ligase rififylin 1 shared papers
Proline-rich protein 5-like 1 shared papers
Serine/threonine-protein kinase B-raf 2 shared papers
Proline-rich protein 5-like 1 shared papers
E3 ubiquitin-protein ligase rififylin 1 shared papers
Guanine nucleotide-binding protein subunit alpha-12 1 shared papers
Guanine nucleotide-binding protein subunit alpha-12 1 shared papers
Ras-related protein M-Ras 1 shared papers
Leucine-rich repeat protein SHOC-2 1 shared papers

Literature · 22 cited papers

BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy. Nat. Commun. · 2022
Structural basis for SHOC2 modulation of RAS signalling. Nature · 2022
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12. Nat. Cell Biol. · 2012
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci. Signal. · 2011
Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci. Signal. · 2010
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci. Signal. · 2009
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol. Cell · 2008
A quantitative atlas of mitotic phosphorylation. Proc. Natl. Acad. Sci. U.S.A. · 2008
Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. J. Proteome Res. · 2008
… and 10 more in the literature graph

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