Envelope glycoprotein C

Function

Major attachment protein that mediates binding of the virus to cell surface heparan sulfate or chondroitin sulfate. Also plays several roles in host immune evasion by inhibiting the host complement cascade activation, and by providing a shield against neutralizing antibodies that interfere with gB-gD, gB-gH/gL or gD-gH/gL interactions (By similarity).

Classification

Family (Pfam)

PF02124 Marek_A

InterPro

GA_GC, Ig-like_dom, Ig-like_dom_sf, Ig-like_fold

Functional cluster

Viral Envelope Glycoproteins

Gene Ontology · 6

• GO:0055036 virion membrane
• GO:0001848 complement binding
• GO:0141018 adhesion of symbiont to host via host extracellular matrix
• GO:0098671 adhesion receptor-mediated virion attachment to host cell
• GO:0046718 symbiont entry into host cell
• GO:0042784 symbiont-mediated suppression of host complement activation

Drugs targeting this protein · 1

• DOCOSANOL inhibitor

Related proteins · sequence + function similarity

• Envelope glycoprotein C 1.00
• Envelope glycoprotein C 0.92
• Envelope glycoprotein C 0.92
• Envelope glycoprotein C 0.92
• Envelope glycoprotein C homolog 0.82
• Envelope glycoprotein C 0.80
• Envelope glycoprotein C 0.79
• Envelope glycoprotein C 0.77
• Envelope glycoprotein C 0.77
• Envelope glycoprotein C homolog 0.76
• Envelope glycoprotein C homolog 0.75
• Envelope glycoprotein C homolog 0.75

Co-cited proteins · studied together in the literature

• Envelope glycoprotein C 1 shared papers
• Complement C3 1 shared papers

Literature · 3 cited papers

• Disulfide bond structure determination and biochemical analysis of glycoprotein C from herpes simplex virus. J. Virol. · 1996
• Complement component C3b binds directly to purified glycoprotein C of herpes simplex virus types 1 and 2. Microb. Pathog. · 1987
• The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J. Gen. Virol. · 1988