Matrix protein 2

UniProt P0DOF8 Organism Influenza A virus (strain A/Udorn/1972 H3N2) Gene M

Also known as: M

Function

Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).

Classification

Family (Pfam): PF00599 Flu_M2
InterPro: Flu_M2
Functional cluster: Photosystem II Reaction-Center & Antimicrobial Peptides

Gene Ontology · 8

Drugs targeting this protein · 1

RIMANTADINE HYDROCHLORIDE inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Matrix protein 1 2 shared papers
Matrix protein 2 3 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers
Matrix protein 2 2 shared papers

Literature · 9 cited papers

Distinct domains of the influenza a virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production. J. Virol. · 2006
Assembly and budding of influenza virus. Virus Res. · 2004
Computational studies of proton transport through the M2 channel. FEBS Lett. · 2003
Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data. FEBS Lett. · 2003
Analysis of the posttranslational modifications of the influenza virus M2 protein. J. Virol. · 1995
Influenza A virus M2 ion channel protein: a structure-function analysis. J. Virol. · 1994
Conservation of the influenza virus membrane protein (M1) amino acid sequence and an open reading frame of RNA segment 7 encoding a second protein (M2) in H1N1 and H3N2 strains. Virology · 1981
Sequences of mRNAs derived from genome RNA segment 7 of influenza virus: colinear and interrupted mRNAs code for overlapping proteins. Proc. Natl. Acad. Sci. U.S.A. · 1981
Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds. Virology · 1991

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