DNA gyrase subunit A

Function

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Classification

Family (Pfam)

PF03989 DNA_gyraseA_C, PF00521 DNA_topoisoIV

InterPro

GyrA, GyrA/parC_rep, Gyrase/topoIV_suA_C, Topo_IIA-like_dom_sf, Topo_IIA_A/C_ab, Topo_IIA_A_a_sf, Topo_IIA_dom_A, Type_II_DNA_Topoisomerases

Functional cluster

Ribosome-Recycling & Clp Protease Factors

Gene Ontology · 8

• GO:0005694 chromosome
• GO:0005737 cytoplasm
• GO:0009330 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
• GO:0005524 ATP binding
• GO:0003677 DNA binding
• GO:0034335 DNA negative supercoiling activity
• GO:0006265 DNA topological change
• GO:0006261 DNA-templated DNA replication

Drugs targeting this protein · 1

• OZENOXACIN inhibitor

Related proteins · sequence + function similarity

• DNA gyrase subunit A 1.00
• DNA gyrase subunit A 1.00
• DNA gyrase subunit A 1.00
• DNA gyrase subunit A 0.93
• DNA gyrase subunit A 0.92
• DNA gyrase subunit A 0.92
• DNA gyrase subunit A 0.91
• DNA gyrase subunit A 0.91
• DNA gyrase subunit A 0.91
• DNA gyrase subunit A 0.91
• DNA gyrase subunit A 0.91
• DNA gyrase subunit A 0.91

Literature · 1 cited papers

• Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence. Proc. Natl. Acad. Sci. U.S.A. · 2002