Serine/threonine-protein kinase BGLF4
Function
Plays many key roles by phosphorylating several proteins including the viral DNA processivity factor BMRF1, EBNA1 or EBNA2. Modifies the host nuclear envelope structure and induces the redistribution of nuclear envelope-associated proteins by phosphorylating host nucleoporins. Subsequently, promotes the nuclear transport of EBV lytic proteins. Required for efficient lytic DNA replication and release of nucleocapsids from the nucleus. Contributes to the compaction of host cell chromatin in cells undergoing lytic replication, presumably by phosphorylating the host condensin complex and host TOP2A. Induces disassembly of the nuclear lamina by phosphorylating with host LMNA. Phosphorylates substrates involved in capsid assembly and DNA packaging. Facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function. Phosphorylates the viral immediate-early protein BZLF1 and inhibits its sumoylation by interacting with host SUMO1 and SUMO2. Phosphorylates also host SAMHD1 and thereby counteracts its antiviral effect by reducing its dNTP hydrolase activity.
Classification
- InterPro
- Kinase-like_dom_sf, Prot_kinase_dom, Tyr_kinase_AS
- Functional cluster
- Tubulins & Mitochondrial Metabolic Enzymes
Gene Ontology · 7
- GO:0042025 host cell nucleus
- GO:0019033 viral tegument
- GO:0005524 ATP binding
- GO:0106310 protein serine kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0039525 symbiont-mediated perturbation of host chromatin organization
- GO:0039548 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
Drugs targeting this protein · 1
- MARIBAVIR inhibitor
Related proteins · sequence + function similarity
- Serine/threonine-protein kinase BGLF4 1.00
- Serine/threonine-protein kinase BGLF4 1.00
- Putative tyrosine kinase 36 0.81
- Viral protein kinase 0.76
- Probable ganciclovir kinase 0.73
- Serine/threonine-protein kinase UL13 0.68
- Probable inactive protein kinase 38 0.65
- Probable ganciclovir kinase 0.61
- Protein kinase ORF16 0.60
- Serine/threonine-protein kinase UL13 homolog 0.59
- Serine/threonine-protein kinase UL13 homolog 0.59
- Serine/threonine-protein kinase UL13 homolog 0.59