Dihydropteroate synthase

Function

Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate, the immediate precursor of folate derivatives.

Classification

Family (Pfam)

PF00809 Pterin_bind

InterPro

DHP_synth-like, DHP_synth_dom, Dihydropteroate_synth-like_sf, Pterin-binding_dom

Functional cluster

Cell-Envelope & Cofactor Biosynthesis Enzymes

Gene Ontology · 5

• GO:0005829 cytosol
• GO:0004156 dihydropteroate synthase activity
• GO:0046872 metal ion binding
• GO:0046656 folic acid biosynthetic process
• GO:0046654 tetrahydrofolate biosynthetic process

Drugs targeting this protein · 2

• DAPSONE inhibitor
• SULFOXONE SODIUM inhibitor

Related proteins · sequence + function similarity

• Dihydropteroate synthase 0.94
• Dihydropteroate synthase 0.94
• Dihydropteroate synthase 0.94
• Inactive dihydropteroate synthase 2 0.74
• Inactive dihydropteroate synthase 2 0.72
• Inactive dihydropteroate synthase 2 0.72
• Inactive dihydropteroate synthase 2 0.72
• Pyridoxal phosphate homeostasis protein 0.66
• Pyridoxal phosphate homeostasis protein 0.66
• Pyridoxal phosphate homeostasis protein 0.66
• Tryptophan synthase alpha chain 0.66
• Tryptophan synthase alpha chain 0.66

Co-cited proteins · studied together in the literature

• Dihydropteroate synthase 1 shared papers

Literature · 3 cited papers

• Massive gene decay in the leprosy bacillus. Nature · 2001
• Cloning and expression of Mycobacterium tuberculosis and Mycobacterium leprae dihydropteroate synthase in Escherichia coli. J. Bacteriol. · 1999
• Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene. FEMS Microbiol. Lett. · 1999