Large ribosomal subunit protein uL22
Also known as: M5005_Spy0049, SPy_0055, rplV
Function
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).
Classification
- Family (Pfam)
- PF00237 Ribosomal_L22
- InterPro
- Ribosomal_uL22, Ribosomal_uL22_bac/chlpt-type, Ribosomal_uL22_bact_org, Ribosomal_uL22_CS, Ribosomal_uL22_sf
- Functional cluster
- Ribosomal Proteins (S5/S18, L17/L22)
Gene Ontology · 4
Drugs targeting this protein · 1
- RETAPAMULIN inhibitor
Related proteins · sequence + function similarity
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
- Large ribosomal subunit protein uL22 1.00
Literature · 2 cited papers
- Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events. J. Infect. Dis. · 2005
- Complete genome sequence of an M1 strain of Streptococcus pyogenes. Proc. Natl. Acad. Sci. U.S.A. · 2001
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