Beta-lactamase SHV-1

UniProt P0AD64 Organism Klebsiella pneumoniae Gene bla, blaSHV-1, shv1 EC 3.5.2.6

Also known as: bla, blaSHV-1, shv1

Function

Broad-spectrum beta-lactamase which confers resistance to penicillins, as well as first- and third-generation cephalosporins. Has nitrocefin-hydrolyzing activity. Inactive against the cephalosporins, cefotaxime and cefoxitin, and the carbapenem, meropenem.

Classification

Family (Pfam): PF13354 Beta-lactamase2
InterPro: Beta-lactam/transpept-like, Beta-lactam_cat, Beta-lactam_class-A, Beta-lactam_class-A_AS
Functional cluster: Cell-Envelope & Peptidoglycan Enzymes

Experimental structures · PDB · 44

1ONG X-ray 1.10A
1Q2P X-ray 2.00A
1RCJ X-ray 1.63A
1SHV X-ray 1.98A
1TDG X-ray 1.80A
1TDL X-ray 1.80A
1VM1 X-ray 2.02A
2A3U X-ray 1.34A
2A49 X-ray 1.43A
2G2U X-ray 1.60A
2G2W X-ray 1.80A
2H0T X-ray 1.60A
… and 32 more

A predicted model is available from AlphaFold.

Gene Ontology · 3

Drugs targeting this protein · 1

RELEBACTAM inhibitor

Related proteins · sequence + function similarity

Co-cited proteins · studied together in the literature

Beta-lactamase inhibitory protein 3 shared papers
Beta-lactamase SHV-2 1 shared papers
Beta-lactamase SHV-5 1 shared papers

Literature · 31 cited papers

Crystal Structures of KPC-2 and SHV-1 beta-Lactamases in Complex with the Boronic Acid Transition State Analog S02030. Antimicrob. Agents Chemother. · 2016
Inhibition of Klebsiella beta-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study. PLoS ONE · 2015
Detecting a quasi-stable imine species on the reaction pathway of SHV-1 beta-lactamase and 6beta-(hydroxymethyl)penicillanic acid sulfone. Biochemistry · 2015
Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition. PLoS ONE · 2014
beta-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme. J. Am. Chem. Soc. · 2013
Design and exploration of novel boronic acid inhibitors reveals important interactions with a clavulanic acid-resistant sulfhydryl-variable (SHV) beta-lactamase. J. Med. Chem. · 2013
Structures of SHV-1 beta-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation. PLoS ONE · 2012
Crystal structure of a preacylation complex of the beta-lactamase inhibitor sulbactam bound to a sulfenamide bond-containing thiol-beta-lactamase. J. Am. Chem. Soc. · 2012
Substitutions at position 105 in SHV family beta-lactamases decrease catalytic efficiency and cause inhibitor resistance. Antimicrob. Agents Chemother. · 2012
The importance of the trans-enamine intermediate as a beta-lactamase inhibition strategy probed in inhibitor-resistant SHV beta-lactamase variants. ChemMedChem · 2012
Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase. Antimicrob. Agents Chemother. · 2011
Specificity and cooperativity at beta-lactamase position 104 in TEM-1/BLIP and SHV-1/BLIP interactions. Proteins · 2011
… and 19 more in the literature graph

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