DNA polymerase catalytic subunit
Function
Replicates viral genomic DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein. Additionally, the polymerase contains an intrinsic ribonuclease H (RNase H) activity that specifically degrades RNA/DNA heteroduplexes or duplex DNA substrates in the 5' to 3' direction. Therefore, it can catalyze the excision of the RNA primers that initiate the synthesis of Okazaki fragments at a replication fork during viral DNA replication (By similarity).
Classification
- Family (Pfam)
- PF00136 DNA_pol_B, PF03104 DNA_pol_B_exo1
- InterPro
- DNA-dir_DNA_pol_B, DNA-dir_DNA_pol_B_CS, DNA-dir_DNA_pol_B_exonuc, DNA-dir_DNA_pol_B_multi_dom, DNA/RNA_pol_sf, DNA_pol_B_thumb, DNA_pol_palm_dom_sf, DNA_pol_type-B, RNaseH-like_sf, RNaseH_sf
- Functional cluster
- Zinc-Finger Nucleic-Acid-Binding & Methyltransferases
Gene Ontology · 7
Drugs targeting this protein · 1
- SORIVUDINE inhibitor
Related proteins · sequence + function similarity
- DNA polymerase catalytic subunit 1.00
- DNA polymerase catalytic subunit 0.93
- DNA polymerase catalytic subunit 0.92
- DNA polymerase 0.91
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.90
- DNA polymerase catalytic subunit 0.89
- DNA polymerase catalytic subunit 0.88
- DNA polymerase catalytic subunit 0.88
Literature · 1 cited papers
- The complete DNA sequence of varicella-zoster virus. J. Gen. Virol. · 1986
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