Glutathione S-transferase P
Also known as: FAEES3, GST3, GSTP1
Function
Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Classification
- Family (Pfam)
- PF14497 GST_C_3, PF02798 GST_N
- InterPro
- Glutathione-S-Trfase_C-like, Glutathione-S-Trfase_C_sf, Glutathione_S-Trfase, Glutathione_S-Trfase_N, GST_C, GST_pi, GST_superfamily, Thioredoxin-like_sf
- Functional cluster
- RNA Polymerase & tRNA Deacylases
Experimental structures · PDB · 68
- 10GS X-ray 2.20A
- 11GS X-ray 2.30A
- 12GS X-ray 2.10A
- 13GS X-ray 1.90A
- 14GS X-ray 2.80A
- 16GS X-ray 1.90A
- 17GS X-ray 1.90A
- 18GS X-ray 1.90A
- 19GS X-ray 1.90A
- 1AQV X-ray 1.94A
- 1AQW X-ray 1.80A
- 1AQX X-ray 2.00A
- … and 56 more
A predicted model is available from AlphaFold.
Gene Ontology · 62
- GO:0005737 cytoplasm
- GO:0005829 cytosol
- GO:0070062 extracellular exosome
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:1904813 ficolin-1-rich granule lumen
- GO:0005739 mitochondrion
- GO:0005634 nucleus
- GO:0034774 secretory granule lumen
- GO:0097057 TRAF2-GSTP1 complex
- GO:0031982 vesicle
- GO:0035731 dinitrosyl-iron complex binding
- GO:0005504 fatty acid binding
- GO:0004602 glutathione peroxidase activity
- GO:0004364 glutathione transferase activity
- GO:0008432 JUN kinase binding
- GO:0070026 nitric oxide binding
- GO:0030291 protein serine/threonine kinase inhibitor activity
- GO:0035730 S-nitrosoglutathione binding
- GO:0015643 toxic substance binding
- GO:0031100 animal organ regeneration
- GO:0071460 cellular response to cell-matrix adhesion
- GO:0071364 cellular response to epidermal growth factor stimulus
- GO:0071385 cellular response to glucocorticoid stimulus
- GO:0032869 cellular response to insulin stimulus
- GO:0071222 cellular response to lipopolysaccharide
- GO:0007417 central nervous system development
- GO:0035726 common myeloid progenitor cell proliferation
- GO:1901687 glutathione derivative biosynthetic process
- GO:0006749 glutathione metabolic process
- GO:0051122 hepoxilin biosynthetic process
- GO:0043651 linoleic acid metabolic process
- GO:0002674 negative regulation of acute inflammatory response
- GO:0043066 negative regulation of apoptotic process
- GO:0043124 negative regulation of canonical NF-kappaB signal transduction
- GO:0070373 negative regulation of ERK1 and ERK2 cascade
- GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
- GO:0110076 negative regulation of ferroptosis
- GO:0048147 negative regulation of fibroblast proliferation
- GO:0032691 negative regulation of interleukin-1 beta production
- GO:0046329 negative regulation of JNK cascade
- GO:0070664 negative regulation of leukocyte proliferation
- GO:0043409 negative regulation of MAPK cascade
- GO:0071638 negative regulation of monocyte chemotactic protein-1 production
- GO:0071672 negative regulation of smooth muscle cell chemotaxis
- GO:0032873 negative regulation of stress-activated MAPK cascade
- GO:0000122 negative regulation of transcription by RNA polymerase II
- GO:0032720 negative regulation of tumor necrosis factor production
- GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
- GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation
- GO:0035732 nitric oxide storage
- GO:0014003 oligodendrocyte development
- GO:0032930 positive regulation of superoxide anion generation
- GO:0006693 prostaglandin metabolic process
- GO:0070372 regulation of ERK1 and ERK2 cascade
- GO:0032872 regulation of stress-activated MAPK cascade
- GO:0043200 response to amino acid
- GO:0032355 response to estradiol
- GO:0045471 response to ethanol
- GO:0033591 response to L-ascorbic acid
- GO:0000302 response to reactive oxygen species
- GO:0006805 xenobiotic metabolic process
Drugs targeting this protein · 1
- EZATIOSTAT HYDROCHLORIDE inhibitor
Related proteins · sequence + function similarity
- Glutathione S-transferase P 1.00
- Glutathione S-transferase P 1.00
- Glutathione S-transferase P 0.97
- Glutathione S-transferase P 0.97
- Glutathione S-transferase P 0.96
- Glutathione S-transferase P 0.96
- Glutathione S-transferase P 0.96
- Glutathione S-transferase P 1 0.95
- Glutathione S-transferase P 0.95
- Glutathione S-transferase P 2 0.95
- Glutathione S-transferase P 0.93
- Glutathione S-transferase P 1 0.67
Co-cited proteins · studied together in the literature
- Glutathione S-transferase Mu 1 4 shared papers
- Glutathione S-transferase Mu 2 2 shared papers
- E3 ubiquitin-protein ligase SMURF2 1 shared papers
- Glutathione S-transferase A1 1 shared papers
- Cyclin-dependent kinase 5 1 shared papers
- Glutathione S-transferase P 1 shared papers
- Glutathione S-transferase Mu 3 1 shared papers
- Glutathione S-transferase Mu 1 1 shared papers
- Glutathione S-transferase Mu 2 1 shared papers
- Glutathione S-transferase Mu 1 1 shared papers
- Argininosuccinate synthase 1 shared papers
- Triosephosphate isomerase 1 shared papers
Literature · 37 cited papers
- SMURF2 predisposes cancer cell toward ferroptosis in GPX4-independent manners by promoting GSTP1 degradation. Mol. Cell · 2023
- N-terminome analysis of the human mitochondrial proteome. Proteomics · 2015
- An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J. Proteomics · 2014
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. J. Proteome Res. · 2013
- N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc. Natl. Acad. Sci. U.S.A. · 2012
- Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Mol. Cell. Proteomics · 2012
- Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. J. Neurochem. · 2011
- Initial characterization of the human central proteome. BMC Syst. Biol. · 2011
- Biosynthesis of 14,15-hepoxilins in human l1236 Hodgkin lymphoma cells and eosinophils. Lipids · 2011
- Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases. Cancer Res. · 2009
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science · 2009
- Rational design of an organometallic glutathione transferase inhibitor. Angew. Chem. Int. Ed. · 2009
- … and 25 more in the literature graph
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