Steryl-sulfatase

Function

Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.

Classification

Family (Pfam)

PF00884 Sulfatase, PF14707 Sulfatase_C

InterPro

Alkaline_phosphatase_core_sf, Sulfatase, Sulfatase_CS, Sulfatase_N

Functional cluster

Immunoglobulin-Domain Cell Adhesion Proteins

Experimental structures · PDB · 2

• 1P49 X-ray 2.60A
• 8EG3 X-ray 2.04A

A predicted model is available from AlphaFold.

Gene Ontology · 16

• GO:0005783 endoplasmic reticulum
• GO:0005788 endoplasmic reticulum lumen
• GO:0005789 endoplasmic reticulum membrane
• GO:0005768 endosome
• GO:0005794 Golgi apparatus
• GO:0043231 intracellular membrane-bounded organelle
• GO:0005764 lysosome
• GO:0016020 membrane
• GO:0005886 plasma membrane
• GO:0004065 arylsulfatase activity
• GO:0046872 metal ion binding
• GO:0004773 steryl-sulfatase activity
• GO:0008484 sulfuric ester hydrolase activity
• GO:0008544 epidermis development
• GO:0007565 female pregnancy
• GO:0006706 steroid catabolic process

Disease associations

• recessive X-linked ichthyosis MONDO:0010622

Drugs targeting this protein · 1

• IROSUSTAT inhibitor

Related proteins · sequence + function similarity

• Arylsulfatase L 0.89
• Arylsulfatase L 0.88
• Arylsulfatase F 0.88
• Arylsulfatase H 0.88
• Arylsulfatase H 0.88
• Arylsulfatase D 0.88
• Arylsulfatase G 0.86
• Arylsulfatase G 0.85
• Arylsulfatase G 0.83
• Arylsulfatase G 0.83
• N-acetylgalactosamine-6-sulfatase 0.83
• N-acetylgalactosamine-6-sulfatase 0.83

Co-cited proteins · studied together in the literature

• Steryl-sulfatase 1 shared papers

Literature · 12 cited papers

• Functional characterization of seven single-nucleotide polymorphisms of the steroid sulfatase gene found in a Japanese population. J. Hum. Genet. · 2013
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. · 2004
• Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. · 2004
• Structure of human estrone sulfatase suggests functional roles of membrane association. J. Biol. Chem. · 2003
• Novel point mutations in the steroid sulfatase gene in patients with X-linked ichthyosis: transfection analysis using the mutated genes. J. Invest. Dermatol. · 2000
• PCR diagnosis of X-linked ichthyosis: identification of a novel mutation (E560P) of the steroid sulfatase gene. Hum. Mutat. · 2000
• Characterization of point mutations in patients with X-linked ichthyosis. Effects on the structure and function of the steroid sulfatase protein. J. Biol. Chem. · 1997
• The human X-linked steroid sulfatase gene and a Y-encoded pseudogene: evidence for an inversion of the Y chromosome during primate evolution. Cell · 1988
• Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange. Cell · 1987
• Characterization of rat and human steroid sulfatases. Biochim. Biophys. Acta · 1989
• Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells. J. Biol. Chem. · 1989
• Identification of point mutations in the steroid sulfatase gene of three patients with X-linked ichthyosis. Am. J. Hum. Genet. · 1992